Cell Senescence Entries for CDK5R1
- Cell Types
- Osteosarcoma
- Cell Lines
- Saos-2, U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Mao et al. (2010) p35 is required for CDK5 activation in cellular senescence. J Biol Chem 285(19)14671-80 (PubMed)
CDK5R1 Gene Information
- HGNC symbol
- CDK5R1
- Aliases
- Nck5a; p35; p35nck5a
- Common name
- cyclin dependent kinase 5 regulatory subunit 1
- Entrez Id
- 8851
- Description
- The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
CDK5R1 Ontologies
- Gene Ontology
-
Process: GO:48511; rhythmic process
GO:18105; peptidyl-serine phosphorylation
GO:226; microtubule cytoskeleton organization
GO:7420; brain development
GO:7213; G protein-coupled acetylcholine receptor signaling pathway
GO:7411; axon guidance
GO:30182; neuron differentiation
GO:31175; neuron projection development
GO:18107; peptidyl-threonine phosphorylation
GO:16241; regulation of macroautophagy
GO:48013; ephrin receptor signaling pathway
GO:61001; regulation of dendritic spine morphogenesis
GO:1764; neuron migration
GO:43525; positive regulation of neuron apoptotic process
GO:35235; ionotropic glutamate receptor signaling pathway
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:7158; neuron cell-cell adhesion
GO:7413; axonal fasciculation
GO:45664; regulation of neuron differentiation
GO:45892; negative regulation of transcription, DNA-templated
GO:32147; activation of protein kinase activity
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:31116; positive regulation of microtubule polymerization
GO:9792; embryo development ending in birth or egg hatching
GO:21549; cerebellum development
GO:21722; superior olivary nucleus maturation
GO:21766; hippocampus development
GO:21799; cerebral cortex radially oriented cell migration
GO:21819; layer formation in cerebral cortex
GO:30517; negative regulation of axon extension
GO:32956; regulation of actin cytoskeleton organization
GO:42501; serine phosphorylation of STAT protein
GO:45860; positive regulation of protein kinase activity
GO:70315; G1 to G0 transition involved in cell differentiation
GO:70507; regulation of microtubule cytoskeleton organization
GO:90314; positive regulation of protein targeting to membrane
GO:98693; regulation of synaptic vesicle cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:42995; cell projection
GO:30425; dendrite
GO:43005; neuron projection
GO:48471; perinuclear region of cytoplasm
GO:30424; axon
GO:43204; perikaryon
GO:14069; postsynaptic density
GO:30426; growth cone
GO:43197; dendritic spine
GO:5829; cytosol
GO:43292; contractile fiber
GO:16533; protein kinase 5 complex
GO:31594; neuromuscular junction
GO:43025; neuronal cell body
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:98793; presynapse
Hide GO termsFunction: GO:16301; kinase activity
GO:5509; calcium ion binding
GO:5515; protein binding
GO:61575; cyclin-dependent protein serine/threonine kinase activator activity
GO:19901; protein kinase binding
GO:43539; protein serine/threonine kinase activator activity
GO:4672; protein kinase activity
GO:45296; cadherin binding
GO:48487; beta-tubulin binding
GO:30295; protein kinase activator activity
GO:43014; alpha-tubulin binding
GO:2020; protease binding
GO:3779; actin binding
GO:35255; ionotropic glutamate receptor binding
GO:46875; ephrin receptor binding
GO:51015; actin filament binding
Homologs of CDK5R1 in Model Organisms
External links
- OMIM
- 603460
- Ensembl
- ENSG00000176749
- Entrez Gene
- 8851
- UniGene
- 500015
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDK5R1
- GeneCards
- CDK5R1