Cell Senescence Entries for CDK6

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Morris et al. (2002) Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function. Oncogene 21(27)4277-88 (PubMed)

CDK6 Gene Information

HGNC symbol
CDK6 
Aliases
PLSTIRE 
Common name
cyclin dependent kinase 6 
Entrez Id
1021
Description
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017].

CDK6 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:30154; cell differentiation
GO:51726; regulation of cell cycle
GO:48699; generation of neurons
GO:45786; negative regulation of cell cycle
GO:8285; negative regulation of cell population proliferation
GO:42127; regulation of cell population proliferation
GO:9615; response to virus
GO:45638; negative regulation of myeloid cell differentiation
GO:3323; type B pancreatic cell development
GO:14002; astrocyte development
GO:45596; negative regulation of cell differentiation
GO:1954; positive regulation of cell-matrix adhesion
GO:82; G1/S transition of mitotic cell cycle
GO:2000145; regulation of cell motility
GO:45668; negative regulation of osteoblast differentiation
GO:48146; positive regulation of fibroblast proliferation
GO:45656; negative regulation of monocyte differentiation
GO:10468; regulation of gene expression
GO:45646; regulation of erythrocyte differentiation
GO:21670; lateral ventricle development
GO:50680; negative regulation of epithelial cell proliferation
GO:2000773; negative regulation of cellular senescence
GO:21542; dentate gyrus development
GO:42063; gliogenesis
GO:43697; cell dedifferentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:2244; hematopoietic progenitor cell differentiation
GO:7219; Notch signaling pathway
GO:10628; positive regulation of gene expression
GO:30097; hemopoiesis
GO:33077; T cell differentiation in thymus
GO:60218; hematopoietic stem cell differentiation
GO:1902036; regulation of hematopoietic stem cell differentiation
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:42995; cell projection
GO:5815; microtubule organizing center
GO:1726; ruffle
GO:5813; centrosome
GO:16592; mediator complex
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:97132; cyclin D2-CDK6 complex
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4693; cyclin-dependent protein serine/threonine kinase activity
GO:8353; RNA polymerase II CTD heptapeptide repeat kinase activity
GO:30332; cyclin binding
GO:98770; FBXO family protein binding
Hide GO terms

Homologs of CDK6 in Model Organisms

Danio rerio
cdk6
Mus musculus
Cdk6
Rattus norvegicus
Cdk6

In other databases

LongevityMap
  • This gene is present as CDK6

External links

OMIM
603368
Ensembl
ENSG00000105810
Entrez Gene
1021
UniGene
119882
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDK6
GeneCards
CDK6