Cell Senescence Entries for CDKN1B

Cell Types
Lung fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
McConnell et al. (1998) Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 8(6)351-4 (PubMed)

CDKN1B Gene Information

HGNC symbol
CDKN1B 
Aliases
KIP1; P27KIP1 
Common name
cyclin dependent kinase inhibitor 1B 
Entrez Id
1027
Description
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].

CDKN1B Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:51726; regulation of cell cycle
GO:60255; regulation of macromolecule metabolic process
GO:42127; regulation of cell population proliferation
GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:8285; negative regulation of cell population proliferation
GO:1902807; negative regulation of cell cycle G1/S phase transition
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:7507; heart development
GO:90398; cellular senescence
GO:30308; negative regulation of cell growth
GO:10942; positive regulation of cell death
GO:45732; positive regulation of protein catabolic process
GO:45930; negative regulation of mitotic cell cycle
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:82; G1/S transition of mitotic cell cycle
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:1904706; negative regulation of vascular associated smooth muscle cell proliferation
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:33673; negative regulation of kinase activity
GO:42326; negative regulation of phosphorylation
GO:1904030; negative regulation of cyclin-dependent protein kinase activity
GO:1905179; negative regulation of cardiac muscle tissue regeneration
GO:71285; cellular response to lithium ion
GO:1666; response to hypoxia
GO:1890; placenta development
GO:6813; potassium ion transport
GO:7096; regulation of exit from mitosis
GO:7219; Notch signaling pathway
GO:7346; regulation of mitotic cell cycle
GO:7605; sensory perception of sound
GO:8219; cell death
GO:8284; positive regulation of cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:9749; response to glucose
GO:14070; response to organic cyclic compound
GO:31116; positive regulation of microtubule polymerization
GO:32355; response to estradiol
GO:43066; negative regulation of apoptotic process
GO:43200; response to amino acid
GO:43434; response to peptide hormone
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:46686; response to cadmium ion
GO:48102; autophagic cell death
GO:48839; inner ear development
GO:50680; negative regulation of epithelial cell proliferation
GO:51271; negative regulation of cellular component movement
GO:60770; negative regulation of epithelial cell proliferation involved in prostate gland development
GO:71236; cellular response to antibiotic
GO:71407; cellular response to organic cyclic compound
GO:1902746; regulation of lens fiber cell differentiation
GO:1902806; regulation of cell cycle G1/S phase transition
GO:43086; negative regulation of catalytic activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5768; endosome
GO:5829; cytosol
GO:31464; Cul4A-RING E3 ubiquitin ligase complex
GO:32991; protein-containing complex
Function: GO:16301; kinase activity
GO:4860; protein kinase inhibitor activity
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:5515; protein binding
GO:51087; chaperone binding
GO:19903; protein phosphatase binding
GO:30332; cyclin binding
GO:19901; protein kinase binding
GO:44877; protein-containing complex binding
GO:30544; Hsp70 protein binding
Hide GO terms

Homologs of CDKN1B in Model Organisms

Caenorhabditis elegans
cki-2
Danio rerio
cdkn1ba
Mus musculus
Cdkn1b
Rattus norvegicus
Cdkn1b

In other databases

LongevityMap
  • This gene is present as CDKN1B

External links

OMIM
600778
Ensembl
ENSG00000111276
Entrez Gene
1027
UniGene
238990
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDKN1B
GeneCards
CDKN1B