The CDKN2A gene and its putative association with human ageing

Cell Senescence Entries for CDKN2A

Cell Types: Lung fibroblast
Cell Lines: TIG-3
Cancer Cell?: No
Method: Overexpression
Type of senescence: Oncogene-induced, Replicative, Stress-induced
Senescence Effect: Induces
Primary Reference: Kato et al. (1998) Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts. FEBS Lett 427(2)203-8 (PubMed)

CDKN2A Gene Information

HGNC symbol: CDKN2A
Aliases: ARF; CDK4I; CDKN2; CMM2; INK4; INK4a; MLM; MTS1; p14; p14ARF; p16; p16INK4a; p19; p19Arf
Common name: cyclin dependent kinase inhibitor 2A
Entrez Id: 1029
Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].

CDKN2A Ontologies

Gene Ontology

Process:

GO:7049; cell cycle
GO:16310; phosphorylation
GO:45892; negative regulation of transcription, DNA-templated
GO:8285; negative regulation of cell population proliferation
GO:90399; replicative senescence
GO:1953; negative regulation of cell-matrix adhesion
GO:30308; negative regulation of cell growth
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:51726; regulation of cell cycle
GO:7265; Ras protein signal transduction
GO:90398; cellular senescence
GO:34393; positive regulation of smooth muscle cell apoptotic process
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:42326; negative regulation of phosphorylation
GO:2000111; positive regulation of macrophage apoptotic process
GO:6915; apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:209; protein polyubiquitination
GO:6364; rRNA processing
GO:16925; protein sumoylation
GO:70534; protein K63-linked ubiquitination
GO:50821; protein stabilization
GO:10628; positive regulation of gene expression
GO:6469; negative regulation of protein kinase activity
GO:31647; regulation of protein stability
GO:8637; apoptotic mitochondrial changes
GO:51444; negative regulation of ubiquitin-protein transferase activity
GO:2000059; negative regulation of ubiquitin-dependent protein catabolic process
GO:1902510; regulation of apoptotic DNA fragmentation
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1900182; positive regulation of protein localization to nucleus
GO:1990000; amyloid fibril formation
GO:33088; negative regulation of immature T cell proliferation in thymus
GO:43517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:10389; regulation of G2/M transition of mitotic cell cycle
GO:1904667; negative regulation of ubiquitin protein ligase activity
GO:2000435; negative regulation of protein neddylation
GO:31648; protein destabilization
GO:30889; negative regulation of B cell proliferation
GO:33235; positive regulation of protein sumoylation
GO:48103; somatic stem cell division
GO:46825; regulation of protein export from nucleus
GO:1901798; positive regulation of signal transduction by p53 class mediator

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:35985; senescence-associated heterochromatin focus
GO:5730; nucleolus
GO:5739; mitochondrion
GO:5654; nucleoplasm
GO:5759; mitochondrial matrix
GO:16604; nuclear body
GO:32991; protein-containing complex

Function:

GO:5515; protein binding
GO:3723; RNA binding
GO:16301; kinase activity
GO:19901; protein kinase binding
GO:51059; NF-kappaB binding
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:3677; DNA binding
GO:19789; SUMO transferase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:2039; p53 binding
GO:97718; disordered domain specific binding
GO:1990948; ubiquitin ligase inhibitor activity
GO:97371; MDM2/MDM4 family protein binding
GO:55105; ubiquitin-protein transferase inhibitor activity

Hide GO terms

Homologs of CDKN2A in Model Organisms

No homologs found

In other databases

GenAge human genes

This gene is present as CDKN2A

LongevityMap

This gene is present as CDKN2A

CellAge gene expression

This gene is present as CDKN2A

Cell Senescence Entries for CDKN2A

CDKN2A Gene Information

CDKN2A Ontologies

Homologs of CDKN2A in Model Organisms

In other databases

External links