Cell Senescence Entries for CDKN2B

Cell Types
Glioblastoma
Cell Lines
T98G, U-251MG, U-373MG
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Fuxe et al. (2000) Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ 11(7)373-84 (PubMed)

CDKN2B Gene Information

HGNC symbol
CDKN2B 
Aliases
CDK4I; INK4B; MTS2; P15; p15INK4b; TP15 
Common name
cyclin dependent kinase inhibitor 2B 
Entrez Id
1030
Description
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].

CDKN2B Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1889; liver development
GO:7568; aging
GO:8285; negative regulation of cell population proliferation
GO:14070; response to organic cyclic compound
GO:30858; positive regulation of epithelial cell differentiation
GO:34097; response to cytokine
GO:48536; spleen development
GO:60253; negative regulation of glial cell proliferation
GO:71560; cellular response to transforming growth factor beta stimulus
GO:1902807; negative regulation of cell cycle G1/S phase transition
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:30219; megakaryocyte differentiation
GO:90398; cellular senescence
GO:31668; cellular response to extracellular stimulus
GO:42326; negative regulation of phosphorylation
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:31670; cellular response to nutrient
GO:50680; negative regulation of epithelial cell proliferation
GO:70316; regulation of G0 to G1 transition
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol
Function: GO:16301; kinase activity
GO:5515; protein binding
GO:19901; protein kinase binding
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
Hide GO terms

Homologs of CDKN2B in Model Organisms

Danio rerio
LOC100329528
Mus musculus
Cdkn2b
Rattus norvegicus
Cdkn2b

In other databases

GenAge human genes
  • This gene is present as CDKN2B
LongevityMap
  • This gene is present as CDKN2B
CellAge gene expression
  • This gene is present as CDKN2B

External links

OMIM
600431
Ensembl
ENSG00000147883
Entrez Gene
1030
UniGene
72901
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDKN2B
GeneCards
CDKN2B