Cell Senescence Entries for CEACAM1

Cell Types
Mammary epithelial
Cell Lines
MCF-10A
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Sappino et al. (2013) The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage. Oncogenesis 1(2)e7 (PubMed)

CEACAM1 Gene Information

HGNC symbol
CEACAM1 
Aliases
BGP; BGP1; CD66a 
Common name
CEA cell adhesion molecule 1 
Entrez Id
634
Description
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010].

CEACAM1 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:7229; integrin-mediated signaling pathway
GO:1525; angiogenesis
GO:30334; regulation of cell migration
GO:16477; cell migration
GO:1558; regulation of cell growth
GO:43116; negative regulation of vascular permeability
GO:32869; cellular response to insulin stimulus
GO:7156; homophilic cell adhesion via plasma membrane adhesion molecules
GO:44319; wound healing, spreading of cells
GO:6469; negative regulation of protein kinase activity
GO:15721; bile acid and bile salt transport
GO:1568; blood vessel development
GO:50860; negative regulation of T cell receptor signaling pathway
GO:14066; regulation of phosphatidylinositol 3-kinase signaling
GO:45717; negative regulation of fatty acid biosynthetic process
GO:70372; regulation of ERK1 and ERK2 cascade
GO:1901143; insulin catabolic process
GO:1915; negative regulation of T cell mediated cytotoxicity
GO:42058; regulation of epidermal growth factor receptor signaling pathway
GO:30853; negative regulation of granulocyte differentiation
GO:2859; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:10594; regulation of endothelial cell migration
GO:32692; negative regulation of interleukin-1 production
GO:35726; common myeloid progenitor cell proliferation
GO:38016; insulin receptor internalization
GO:38158; granulocyte colony-stimulating factor signaling pathway
GO:43318; negative regulation of cytotoxic T cell degranulation
GO:45601; regulation of endothelial cell differentiation
GO:51055; negative regulation of lipid biosynthetic process
GO:60312; regulation of blood vessel remodeling
GO:90331; negative regulation of platelet aggregation
GO:98742; cell-cell adhesion via plasma-membrane adhesion molecules
GO:1903385; regulation of homophilic cell adhesion
GO:1903670; regulation of sprouting angiogenesis
GO:2000346; negative regulation of hepatocyte proliferation
GO:2001214; positive regulation of vasculogenesis
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5912; adherens junction
GO:30054; cell junction
GO:16324; apical plasma membrane
GO:42995; cell projection
GO:9986; cell surface
GO:16328; lateral plasma membrane
GO:42101; T cell receptor complex
GO:5887; integral component of plasma membrane
GO:31528; microvillus membrane
GO:30658; transport vesicle membrane
GO:70062; extracellular exosome
GO:35579; specific granule membrane
GO:70821; tertiary granule membrane
GO:9925; basal plasma membrane
GO:5911; cell-cell junction
Function: GO:42802; identical protein binding
GO:3779; actin binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:46983; protein dimerization activity
GO:5516; calmodulin binding
GO:15125; bile acid transmembrane transporter activity
GO:3674; molecular_function
GO:19903; protein phosphatase binding
GO:19900; kinase binding
GO:1990782; protein tyrosine kinase binding
GO:31005; filamin binding
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Homologs of CEACAM1 in Model Organisms

No homologs found

External links

OMIM
109770
Ensembl
ENSG00000079385
Entrez Gene
634
UniGene
512682
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CEACAM1
GeneCards
CEACAM1