Cell Senescence Entries for CEBPB

Cell Types
Prostate cancer
Cell Lines
LNCaP
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Barakat et al. (2016) CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells. Oncogene 34(48)5912-22 (PubMed)

CEBPB Gene Information

HGNC symbol
CEBPB 
Aliases
C/EBP-beta; CRP2; IL6DBP; LAP; NFIL6; TCF5 
Common name
CCAAT enhancer binding protein beta 
Entrez Id
1051
Description
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013].

CEBPB Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:42742; defense response to bacterium
GO:34976; response to endoplasmic reticulum stress
GO:45595; regulation of cell differentiation
GO:6954; inflammatory response
GO:6955; immune response
GO:32753; positive regulation of interleukin-4 production
GO:45944; positive regulation of transcription by RNA polymerase II
GO:120162; positive regulation of cold-induced thermogenesis
GO:70059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:45893; positive regulation of transcription, DNA-templated
GO:1990440; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:45600; positive regulation of fat cell differentiation
GO:42130; negative regulation of T cell proliferation
GO:1541; ovarian follicle development
GO:6953; acute-phase response
GO:45670; regulation of osteoclast differentiation
GO:72574; hepatocyte proliferation
GO:97421; liver regeneration
GO:70169; positive regulation of biomineral tissue development
GO:2000120; positive regulation of sodium-dependent phosphate transport
GO:1889; liver development
GO:1892; embryonic placenta development
GO:7613; memory
GO:10628; positive regulation of gene expression
GO:30182; neuron differentiation
GO:32496; response to lipopolysaccharide
GO:32675; regulation of interleukin-6 production
GO:33598; mammary gland epithelial cell proliferation
GO:43524; negative regulation of neuron apoptotic process
GO:45444; fat cell differentiation
GO:45669; positive regulation of osteoblast differentiation
GO:45892; negative regulation of transcription, DNA-templated
GO:50729; positive regulation of inflammatory response
GO:50873; brown fat cell differentiation
GO:60644; mammary gland epithelial cell differentiation
GO:71222; cellular response to lipopolysaccharide
GO:71230; cellular response to amino acid stimulus
GO:71347; cellular response to interleukin-1
GO:71407; cellular response to organic cyclic compound
GO:1901329; regulation of odontoblast differentiation
GO:2001198; regulation of dendritic cell differentiation
GO:140467; integrated stress response signaling
GO:61515; myeloid cell development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:36488; CHOP-C/EBP complex
GO:1990647; C/EBP complex
GO:779; condensed chromosome, centromeric region
GO:16363; nuclear matrix
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:42803; protein homodimerization activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:976; transcription cis-regulatory region binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:19900; kinase binding
GO:31490; chromatin DNA binding
GO:35035; histone acetyltransferase binding
GO:35259; glucocorticoid receptor binding
GO:42802; identical protein binding
GO:42826; histone deacetylase binding
GO:43565; sequence-specific DNA binding
GO:44389; ubiquitin-like protein ligase binding
GO:46982; protein heterodimerization activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Hide GO terms

Homologs of CEBPB in Model Organisms

Danio rerio
cebpb
Mus musculus
Cebpb
Rattus norvegicus
Cebpb

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cebpb
GenAge human genes
  • This gene is present as CEBPB

External links

OMIM
189965
Ensembl
ENSG00000172216
Entrez Gene
1051
UniGene
719041
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CEBPB
GeneCards
CEBPB