Cell Senescence Entries for CHEK2

Cell Types
Cervical cancer, Colon cancer
Cell Lines
DLD1, HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Chen et al. (2005) Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer. Cancer Res 65(14)6017-21 (PubMed)

CHEK2 Gene Information

HGNC symbol
CHEK2 
Aliases
bA444G7; CDS1; CHK2; HuCds1; PP1425; RAD53 
Common name
checkpoint kinase 2 
Entrez Id
11200
Description
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

CHEK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:51301; cell division
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45893; positive regulation of transcription, DNA-templated
GO:6302; double-strand break repair
GO:42176; regulation of protein catabolic process
GO:46777; protein autophosphorylation
GO:50821; protein stabilization
GO:44257; cellular protein catabolic process
GO:90307; mitotic spindle assembly
GO:1901796; regulation of signal transduction by p53 class mediator
GO:90399; replicative senescence
GO:77; DNA damage checkpoint signaling
GO:6975; DNA damage induced protein phosphorylation
GO:86; G2/M transition of mitotic cell cycle
GO:31573; mitotic intra-S DNA damage checkpoint signaling
GO:42770; signal transduction in response to DNA damage
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:44773; mitotic DNA damage checkpoint signaling
GO:1934; positive regulation of protein phosphorylation
GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:10332; response to gamma radiation
GO:18105; peptidyl-serine phosphorylation
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:71466; cellular response to xenobiotic stimulus
GO:71480; cellular response to gamma radiation
GO:1903416; response to glycoside
GO:1903926; cellular response to bisphenol A
GO:2000002; negative regulation of DNA damage checkpoint
GO:2000210; positive regulation of anoikis
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:16605; PML body
GO:5737; cytoplasm
Function: GO:4672; protein kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:31625; ubiquitin protein ligase binding
GO:42803; protein homodimerization activity
GO:42802; identical protein binding
GO:19901; protein kinase binding
Hide GO terms

Homologs of CHEK2 in Model Organisms

Caenorhabditis elegans
CELE_T08D2.7
Danio rerio
chek2
Drosophila melanogaster
lok
Mus musculus
Chek2
Rattus norvegicus
Chek2
Saccharomyces cerevisiae
DUN1
Schizosaccharomyces pombe
cds1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Chek2
  • A homolog of this gene for Saccharomyces cerevisiae is present as DUN1
GenAge human genes
  • This gene is present as CHEK2

External links

OMIM
604373
Ensembl
ENSG00000183765
Entrez Gene
11200
UniGene
505297
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CHEK2
GeneCards
CHEK2