Cell Senescence Entries for CHUK

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ho et al. (2012) HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. J Virol 86(17)9474-83 (PubMed)

CHUK Gene Information

HGNC symbol
CHUK 
Aliases
IkBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16 
Common name
component of inhibitor of nuclear factor kappa B kinase complex 
Entrez Id
1147
Description
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008].

CHUK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45087; innate immune response
GO:6954; inflammatory response
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:9615; response to virus
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:71356; cellular response to tumor necrosis factor
GO:18105; peptidyl-serine phosphorylation
GO:6955; immune response
GO:9653; anatomical structure morphogenesis
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:7249; I-kappaB kinase/NF-kappaB signaling
GO:7252; I-kappaB phosphorylation
GO:32727; positive regulation of interferon-alpha production
GO:34614; cellular response to reactive oxygen species
GO:38061; NIK/NF-kappaB signaling
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:45893; positive regulation of transcription, DNA-templated
GO:71276; cellular response to cadmium ion
GO:98586; cellular response to virus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:9898; cytoplasmic side of plasma membrane
GO:35631; CD40 receptor complex
GO:8385; IkappaB kinase complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:8384; IkappaB kinase activity
GO:46982; protein heterodimerization activity
GO:97110; scaffold protein binding
GO:1990459; transferrin receptor binding
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Homologs of CHUK in Model Organisms

Danio rerio
chuk
Mus musculus
Chuk
Rattus norvegicus
Chuk

External links

OMIM
600664
Ensembl
ENSG00000213341
Entrez Gene
1147
UniGene
198998
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CHUK
GeneCards
CHUK