Cell Senescence Entries for CIT

Cell Types
Melanoma
Cell Lines
A375P
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

CIT Gene Information

HGNC symbol
CIT 
Aliases
CITK; CRIK; KIAA0949; STK21 
Common name
citron rho-interacting serine/threonine kinase 
Entrez Id
11113
Description
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].

CIT Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:30154; cell differentiation
GO:43086; negative regulation of catalytic activity
GO:7399; nervous system development
GO:48699; generation of neurons
GO:281; mitotic cytokinesis
GO:31032; actomyosin structure organization
GO:18107; peptidyl-threonine phosphorylation
GO:278; mitotic cell cycle
GO:32467; positive regulation of cytokinesis
GO:35331; negative regulation of hippo signaling
GO:51402; neuron apoptotic process
GO:86; G2/M transition of mitotic cell cycle
GO:1889; liver development
GO:7030; Golgi organization
GO:8064; regulation of actin polymerization or depolymerization
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5829; cytosol
GO:5634; nucleus
GO:5886; plasma membrane
GO:30496; midbody
GO:31985; Golgi cisterna
GO:32154; cleavage furrow
GO:43025; neuronal cell body
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:17124; SH3 domain binding
GO:5515; protein binding
GO:1223; transcription coactivator binding
GO:19901; protein kinase binding
GO:30165; PDZ domain binding
GO:30291; protein serine/threonine kinase inhibitor activity
GO:97110; scaffold protein binding
Hide GO terms

Homologs of CIT in Model Organisms

Caenorhabditis elegans
CELE_W02B8.2
Danio rerio
LOC100329792
Drosophila melanogaster
sti
Mus musculus
Cit
Rattus norvegicus
Cit
Saccharomyces cerevisiae
KCC4

In other databases

CellAge gene expression
  • This gene is present as CIT

External links

OMIM
605629
Ensembl
ENSG00000122966
Entrez Gene
11113
UniGene
119594
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CIT
GeneCards
CIT