Cell Senescence Entries for CLPP
- Cell Types
- Liver cancer
- Cell Lines
- Hep G2, Huh7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Sen et al. (2020) Senescent Hepatocytes in Decompensated Liver Show Reduced UPRMT and Its Key Player, CLPP, Attenuates Senescence In Vitro. Cell Mol Gastroenterol Hepatol 8(1)73-94 (PubMed)
CLPP Gene Information
- HGNC symbol
- CLPP
- Aliases
- Common name
- caseinolytic mitochondrial matrix peptidase proteolytic subunit
- Entrez Id
- 8192
- Description
- The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008].
CLPP Ontologies
- Gene Ontology
-
Process: GO:6508; proteolysis
GO:51603; proteolysis involved in cellular protein catabolic process
GO:33619; membrane protein proteolysis
GO:6515; protein quality control for misfolded or incompletely synthesized proteins
Cellular component: GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:9368; endopeptidase Clp complex
Hide GO termsFunction: GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4252; serine-type endopeptidase activity
GO:8236; serine-type peptidase activity
GO:4176; ATP-dependent peptidase activity
GO:4175; endopeptidase activity
GO:51117; ATPase binding
GO:42802; identical protein binding
Homologs of CLPP in Model Organisms
- Caenorhabditis elegans
- clpp-1
- Danio rerio
- clpp
- Drosophila melanogaster
- CG5045
- Mus musculus
- Clpp
- Rattus norvegicus
- Clpp
External links
- OMIM
- 601119
- Ensembl
- ENSG00000125656
- Entrez Gene
- 8192
- UniGene
- 515092
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CLPP
- GeneCards
- CLPP