Cell Senescence Entries for CLU

Cell Types
Cervical cancer
Cell Lines
L-02
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2019) Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. Ecotoxicol Environ Saf 183(2)109465 (PubMed)

CLU Gene Information

HGNC symbol
CLU 
Aliases
APOJ; CLI; CLU1; CLU2; KUB1; SGP-2; SP-40; TRPM-2 
Common name
clusterin 
Entrez Id
1191
Description
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011].

CLU Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:2376; immune system process
GO:45087; innate immune response
GO:43065; positive regulation of apoptotic process
GO:42127; regulation of cell population proliferation
GO:6958; complement activation, classical pathway
GO:50821; protein stabilization
GO:42981; regulation of apoptotic process
GO:9615; response to virus
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:10628; positive regulation of gene expression
GO:48260; positive regulation of receptor-mediated endocytosis
GO:6629; lipid metabolic process
GO:61077; chaperone-mediated protein folding
GO:1902230; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1901216; positive regulation of neuron death
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000060; positive regulation of ubiquitin-dependent protein catabolic process
GO:43691; reverse cholesterol transport
GO:6956; complement activation
GO:51788; response to misfolded protein
GO:1905907; negative regulation of amyloid fibril formation
GO:31333; negative regulation of protein-containing complex assembly
GO:17038; protein import
GO:1900221; regulation of amyloid-beta clearance
GO:1902430; negative regulation of amyloid-beta formation
GO:1905908; positive regulation of amyloid fibril formation
GO:31334; positive regulation of protein-containing complex assembly
GO:1836; release of cytochrome c from mitochondria
GO:902; cell morphogenesis
GO:1774; microglial cell activation
GO:2434; immune complex clearance
GO:32286; central nervous system myelin maintenance
GO:32760; positive regulation of tumor necrosis factor production
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:51131; chaperone-mediated protein complex assembly
GO:60548; negative regulation of cell death
GO:61518; microglial cell proliferation
GO:61740; protein targeting to lysosome involved in chaperone-mediated autophagy
GO:90201; negative regulation of release of cytochrome c from mitochondria
GO:1901214; regulation of neuron death
GO:1902004; positive regulation of amyloid-beta formation
GO:1902847; regulation of neuronal signal transduction
GO:1902949; positive regulation of tau-protein kinase activity
GO:1902998; positive regulation of neurofibrillary tangle assembly
GO:1903573; negative regulation of response to endoplasmic reticulum stress
GO:1905892; negative regulation of cellular response to thapsigargin
GO:1905895; negative regulation of cellular response to tunicamycin
Cellular component: GO:5615; extracellular space
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:31410; cytoplasmic vesicle
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:43231; intracellular membrane-bounded organelle
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5576; extracellular region
GO:48471; perinuclear region of cytoplasm
GO:31966; mitochondrial membrane
GO:9986; cell surface
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:72562; blood microparticle
GO:42583; chromaffin granule
GO:31093; platelet alpha granule lumen
GO:5856; cytoskeleton
GO:5794; Golgi apparatus
GO:34366; spherical high-density lipoprotein particle
GO:71944; cell periphery
GO:45202; synapse
GO:97418; neurofibrillary tangle
GO:97440; apical dendrite
GO:99020; perinuclear endoplasmic reticulum lumen
Function: GO:5515; protein binding
GO:31625; ubiquitin protein ligase binding
GO:51082; unfolded protein binding
GO:1540; amyloid-beta binding
GO:5102; signaling receptor binding
GO:50750; low-density lipoprotein particle receptor binding
GO:48156; tau protein binding
GO:51087; chaperone binding
GO:44877; protein-containing complex binding
GO:140597; protein carrier activity
GO:51787; misfolded protein binding
Hide GO terms

Homologs of CLU in Model Organisms

Danio rerio
clu
Mus musculus
Clu
Rattus norvegicus
Clu

In other databases

GenAge human genes
  • This gene is present as CLU
GenAge microarray genes
  • This gene is present as CLU
LongevityMap
  • This gene is present as CLU

External links

OMIM
185430
Ensembl
ENSG00000120885
Entrez Gene
1191
UniGene
436657
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CLU
GeneCards
CLU