Cell Senescence Entries for CREG1
- Cell Types
- Fibrosarcoma, Li-Fraumeni syndrome cells, Osteosarcoma
- Cell Lines
- HT1080, MDAH041, MDAH087, Saos-2, U2OS
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Moolmuang et al. (2011) CREG1 enhances p16(INK4a) -induced cellular senescence. Cell Cycle 10(3)518-30 (PubMed)
CREG1 Gene Information
- HGNC symbol
- CREG1
- Aliases
- CREG
- Common name
- cellular repressor of E1A stimulated genes 1
- Entrez Id
- 8804
- Description
- The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008].
CREG1 Ontologies
- Gene Ontology
-
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6357; regulation of transcription by RNA polymerase II
GO:6355; regulation of transcription, DNA-templated
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
GO:70062; extracellular exosome
GO:35578; azurophil granule lumen
GO:5667; transcription regulator complex
Hide GO termsFunction: GO:3714; transcription corepressor activity
Homologs of CREG1 in Model Organisms
In other databases
- CellAge gene expression
- This gene is present as CREG1
External links
- OMIM
- 618055
- Ensembl
- ENSG00000143162
- Entrez Gene
- 8804
- UniGene
- 5710
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CREG1
- GeneCards
- CREG1