Cell Senescence Entries for CSNK2A1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Ryu et al. (2006) Downregulation of protein kinase CKII is associated with cellular senescence. FEBS Lett 580(3)988-94 (PubMed)

CSNK2A1 Gene Information

HGNC symbol
CSNK2A1 
Aliases
Cka1; Cka2 
Common name
casein kinase 2 alpha 1 
Entrez Id
1457
Description
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018].

CSNK2A1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:16055; Wnt signaling pathway
GO:48511; rhythmic process
GO:18105; peptidyl-serine phosphorylation
GO:30177; positive regulation of Wnt signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:45732; positive regulation of protein catabolic process
GO:18107; peptidyl-threonine phosphorylation
GO:51726; regulation of cell cycle
GO:7165; signal transduction
GO:30307; positive regulation of cell growth
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:61077; chaperone-mediated protein folding
GO:2001234; negative regulation of apoptotic signaling pathway
GO:1905818; regulation of chromosome separation
GO:2000059; negative regulation of ubiquitin-dependent protein catabolic process
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:31519; PcG protein complex
GO:5829; cytosol
GO:5886; plasma membrane
GO:16581; NuRD complex
GO:5956; protein kinase CK2 complex
GO:16580; Sin3 complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:51879; Hsp90 protein binding
GO:47485; protein N-terminus binding
Hide GO terms

Homologs of CSNK2A1 in Model Organisms

Mus musculus
Csnk2a2
Rattus norvegicus
Csnk2a2

External links

OMIM
115440
Ensembl
ENSG00000101266
Entrez Gene
1457
UniGene
644056
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CSNK2A1
GeneCards
CSNK2A1