Cell Senescence Entries for CTH
- Cell Types
- Melanoma
- Cell Lines
- A375, Mel Ho, SK-MEL-28, UACC-62
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Leikam et al. (2014) Cystathionase mediates senescence evasion in melanocytes and melanoma cells. Oncogene 33(6)771-82 (PubMed)
CTH Gene Information
- HGNC symbol
- CTH
- Aliases
- CSE
- Common name
- cystathionine gamma-lyase
- Entrez Id
- 1491
- Description
- This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
CTH Ontologies
- Gene Ontology
-
Process: GO:6629; lipid metabolic process
GO:8652; cellular amino acid biosynthetic process
GO:51289; protein homotetramerization
GO:30968; endoplasmic reticulum unfolded protein response
GO:19344; cysteine biosynthetic process
GO:19346; transsulfuration
GO:70814; hydrogen sulfide biosynthetic process
GO:6534; cysteine metabolic process
GO:18272; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:19343; cysteine biosynthetic process via cystathionine
GO:44524; protein sulfhydration
GO:1904831; positive regulation of aortic smooth muscle cell differentiation
GO:43066; negative regulation of apoptotic process
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:1990830; cellular response to leukemia inhibitory factor
GO:2001234; negative regulation of apoptotic signaling pathway
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
Hide GO termsFunction: GO:3824; catalytic activity
GO:16829; lyase activity
GO:5515; protein binding
GO:30170; pyridoxal phosphate binding
GO:42802; identical protein binding
GO:5516; calmodulin binding
GO:4123; cystathionine gamma-lyase activity
GO:16846; carbon-sulfur lyase activity
GO:44540; L-cystine L-cysteine-lyase (deaminating)
GO:80146; L-cysteine desulfhydrase activity
Homologs of CTH in Model Organisms
- Caenorhabditis elegans
- cth-1
- Danio rerio
- cthl
- Drosophila melanogaster
- Eip55E
- Mus musculus
- Cth
- Rattus norvegicus
- Cth
- Saccharomyces cerevisiae
- CYS3
- Schizosaccharomyces pombe
- SPBC428.11
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as cth-1
External links
- OMIM
- 607657
- Ensembl
- ENSG00000116761
- Entrez Gene
- 1491
- UniGene
- 19904
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CTH
- GeneCards
- CTH