Cell Senescence Entries for CTNNB1

Cell Types
Bone marrow mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Gu et al. (2014) Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway. Mol Cell Biochem 387(1-2)27-37 (PubMed)

CTNNB1 Gene Information

HGNC symbol
CTNNB1 
Aliases
armadillo; beta-catenin; CTNNB 
Common name
catenin beta 1 
Entrez Id
1499
Description
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

CTNNB1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:7155; cell adhesion
GO:16055; Wnt signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:7399; nervous system development
GO:43065; positive regulation of apoptotic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:9410; response to xenobiotic stimulus
GO:8285; negative regulation of cell population proliferation
GO:43066; negative regulation of apoptotic process
GO:60070; canonical Wnt signaling pathway
GO:32355; response to estradiol
GO:1569; branching involved in blood vessel morphogenesis
GO:1904948; midbrain dopaminergic neuron differentiation
GO:16525; negative regulation of angiogenesis
GO:34333; adherens junction assembly
GO:35995; detection of muscle stretch
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:71363; cellular response to growth factor stimulus
GO:45765; regulation of angiogenesis
GO:19827; stem cell population maintenance
GO:35315; hair cell differentiation
GO:98609; cell-cell adhesion
GO:90279; regulation of calcium ion import
GO:2000008; regulation of protein localization to cell surface
GO:1904954; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:71681; cellular response to indole-3-methanol
GO:1837; epithelial to mesenchymal transition
GO:34394; protein localization to cell surface
GO:33234; negative regulation of protein sumoylation
GO:72182; regulation of nephron tubule epithelial cell differentiation
GO:32212; positive regulation of telomere maintenance via telomerase
GO:51973; positive regulation of telomerase activity
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:2052; positive regulation of neuroblast proliferation
GO:10909; positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:30997; regulation of centriole-centriole cohesion
GO:36023; embryonic skeletal limb joint morphogenesis
GO:43525; positive regulation of neuron apoptotic process
GO:44334; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:44336; canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:44339; canonical Wnt signaling pathway involved in osteoblast differentiation
GO:45976; negative regulation of mitotic cell cycle, embryonic
GO:48145; regulation of fibroblast proliferation
GO:48660; regulation of smooth muscle cell proliferation
GO:50767; regulation of neurogenesis
GO:51571; positive regulation of histone H3-K4 methylation
GO:61154; endothelial tube morphogenesis
GO:61324; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:61549; sympathetic ganglion development
GO:70602; regulation of centromeric sister chromatid cohesion
GO:72497; mesenchymal stem cell differentiation
GO:1990138; neuron projection extension
GO:45597; positive regulation of cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:578; embryonic axis specification
GO:904; cell morphogenesis involved in differentiation
GO:1501; skeletal system development
GO:1570; vasculogenesis
GO:1658; branching involved in ureteric bud morphogenesis
GO:1701; in utero embryonic development
GO:1702; gastrulation with mouth forming second
GO:1706; endoderm formation
GO:1708; cell fate specification
GO:1709; cell fate determination
GO:1711; endodermal cell fate commitment
GO:1764; neuron migration
GO:1822; kidney development
GO:1840; neural plate development
GO:1894; tissue homeostasis
GO:1944; vasculature development
GO:2053; positive regulation of mesenchymal cell proliferation
GO:2089; lens morphogenesis in camera-type eye
GO:3266; regulation of secondary heart field cardioblast proliferation
GO:3338; metanephros morphogenesis
GO:3340; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:6357; regulation of transcription by RNA polymerase II
GO:7160; cell-matrix adhesion
GO:7268; chemical synaptic transmission
GO:7398; ectoderm development
GO:7403; glial cell fate determination
GO:7507; heart development
GO:8283; cell population proliferation
GO:8284; positive regulation of cell population proliferation
GO:9948; anterior/posterior axis specification
GO:9950; dorsal/ventral axis specification
GO:9953; dorsal/ventral pattern formation
GO:9954; proximal/distal pattern formation
GO:10468; regulation of gene expression
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:16331; morphogenesis of embryonic epithelium
GO:21819; layer formation in cerebral cortex
GO:22009; central nervous system vasculogenesis
GO:22405; hair cycle process
GO:30097; hemopoiesis
GO:30154; cell differentiation
GO:30182; neuron differentiation
GO:30217; T cell differentiation
GO:30316; osteoclast differentiation
GO:30324; lung development
GO:30539; male genitalia development
GO:30856; regulation of epithelial cell differentiation
GO:30858; positive regulation of epithelial cell differentiation
GO:30900; forebrain development
GO:30901; midbrain development
GO:30902; hindbrain development
GO:31016; pancreas development
GO:31069; hair follicle morphogenesis
GO:31641; regulation of myelination
GO:32331; negative regulation of chondrocyte differentiation
GO:32968; positive regulation of transcription elongation from RNA polymerase II promoter
GO:33077; T cell differentiation in thymus
GO:34332; adherens junction organization
GO:34613; cellular protein localization
GO:35050; embryonic heart tube development
GO:35112; genitalia morphogenesis
GO:35115; embryonic forelimb morphogenesis
GO:35116; embryonic hindlimb morphogenesis
GO:36520; astrocyte-dopaminergic neuron signaling
GO:42127; regulation of cell population proliferation
GO:42129; regulation of T cell proliferation
GO:42475; odontogenesis of dentin-containing tooth
GO:42733; embryonic digit morphogenesis
GO:42981; regulation of apoptotic process
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:43410; positive regulation of MAPK cascade
GO:43588; skin development
GO:44093; positive regulation of molecular function
GO:44338; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO:45453; bone resorption
GO:45595; regulation of cell differentiation
GO:45596; negative regulation of cell differentiation
GO:45603; positive regulation of endothelial cell differentiation
GO:45667; regulation of osteoblast differentiation
GO:45669; positive regulation of osteoblast differentiation
GO:45670; regulation of osteoclast differentiation
GO:45671; negative regulation of osteoclast differentiation
GO:45743; positive regulation of fibroblast growth factor receptor signaling pathway
GO:48469; cell maturation
GO:48489; synaptic vesicle transport
GO:48513; animal organ development
GO:48538; thymus development
GO:48568; embryonic organ development
GO:48599; oocyte development
GO:48617; embryonic foregut morphogenesis
GO:48643; positive regulation of skeletal muscle tissue development
GO:48715; negative regulation of oligodendrocyte differentiation
GO:50768; negative regulation of neurogenesis
GO:50808; synapse organization
GO:51145; smooth muscle cell differentiation
GO:51884; regulation of timing of anagen
GO:60066; oviduct development
GO:60173; limb development
GO:60439; trachea morphogenesis
GO:60440; trachea formation
GO:60441; epithelial tube branching involved in lung morphogenesis
GO:60479; lung cell differentiation
GO:60484; lung-associated mesenchyme development
GO:60492; lung induction
GO:60742; epithelial cell differentiation involved in prostate gland development
GO:60769; positive regulation of epithelial cell proliferation involved in prostate gland development
GO:60789; hair follicle placode formation
GO:60916; mesenchymal cell proliferation involved in lung development
GO:61047; positive regulation of branching involved in lung morphogenesis
GO:61198; fungiform papilla formation
GO:61550; cranial ganglion development
GO:72033; renal vesicle formation
GO:72053; renal inner medulla development
GO:72054; renal outer medulla development
GO:72079; nephron tubule formation
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:97091; synaptic vesicle clustering
GO:1901215; negative regulation of neuron death
GO:1903204; negative regulation of oxidative stress-induced neuron death
GO:1904796; regulation of core promoter binding
GO:1904798; positive regulation of core promoter binding
GO:1904888; cranial skeletal system development
GO:1990403; embryonic brain development
GO:1990791; dorsal root ganglion development
GO:2000017; positive regulation of determination of dorsal identity
GO:2000179; positive regulation of neural precursor cell proliferation
GO:2001234; negative regulation of apoptotic signaling pathway
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
GO:5912; adherens junction
GO:30054; cell junction
GO:42995; cell projection
GO:45202; synapse
GO:48471; perinuclear region of cytoplasm
GO:16323; basolateral plasma membrane
GO:5815; microtubule organizing center
GO:922; spindle pole
GO:5813; centrosome
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:32991; protein-containing complex
GO:16342; catenin complex
GO:5667; transcription regulator complex
GO:1990907; beta-catenin-TCF complex
GO:5911; cell-cell junction
GO:16328; lateral plasma membrane
GO:30877; beta-catenin destruction complex
GO:71944; cell periphery
GO:5938; cell cortex
GO:1990909; Wnt signalosome
GO:791; euchromatin
GO:32993; protein-DNA complex
GO:70369; beta-catenin-TCF7L2 complex
GO:5916; fascia adherens
GO:5923; bicellular tight junction
GO:14704; intercalated disc
GO:16327; apicolateral plasma membrane
GO:16600; flotillin complex
GO:30018; Z disc
GO:30027; lamellipodium
GO:31253; cell projection membrane
GO:31528; microvillus membrane
GO:34750; Scrib-APC-beta-catenin complex
GO:42734; presynaptic membrane
GO:43296; apical junction complex
GO:45177; apical part of cell
GO:45211; postsynaptic membrane
GO:90575; RNA polymerase II transcription regulator complex
GO:98685; Schaffer collateral - CA1 synapse
GO:98831; presynaptic active zone cytoplasmic component
GO:99092; postsynaptic density, intracellular component
GO:1990711; beta-catenin-ICAT complex
Function: GO:5515; protein binding
GO:45296; cadherin binding
GO:3713; transcription coactivator activity
GO:19899; enzyme binding
GO:8022; protein C-terminus binding
GO:44325; transmembrane transporter binding
GO:19903; protein phosphatase binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:16922; nuclear receptor binding
GO:8013; beta-catenin binding
GO:70411; I-SMAD binding
GO:46332; SMAD binding
GO:140297; DNA-binding transcription factor binding
GO:1990226; histone methyltransferase binding
GO:19900; kinase binding
GO:45294; alpha-catenin binding
GO:1221; transcription coregulator binding
GO:3682; chromatin binding
GO:30331; estrogen receptor binding
GO:19901; protein kinase binding
GO:97718; disordered domain specific binding
Hide GO terms

Homologs of CTNNB1 in Model Organisms

Danio rerio
ctnnb1
Drosophila melanogaster
arm
Mus musculus
Ctnnb1
Rattus norvegicus
Ctnnb1

In other databases

GenAge human genes
  • This gene is present as CTNNB1

External links

OMIM
116806
Ensembl
ENSG00000168036
Entrez Gene
1499
UniGene
712929
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CTNNB1
GeneCards
CTNNB1