Cell Senescence Entries for CUX1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Ramdzan et al. (2014) RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol 12(3)e1001807 (PubMed)
CUX1 Gene Information
- HGNC symbol
- CUX1
- Aliases
- CASP; CDP; CDP/Cut; CDP/Cux; CDP1; Clox; CUT; CUTL1; CUX; Cux/CDP; GOLIM6
- Common name
- cut like homeobox 1
- Entrez Id
- 1523
- Description
- The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011].
CUX1 Ontologies
- Gene Ontology
-
Process: GO:6891; intra-Golgi vesicle-mediated transport
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:50775; positive regulation of dendrite morphogenesis
GO:122; negative regulation of transcription by RNA polymerase II
GO:7275; multicellular organism development
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:139; Golgi membrane
GO:30173; integral component of Golgi membrane
GO:5634; nucleus
GO:785; chromatin
GO:5829; cytosol
Hide GO termsFunction: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
Homologs of CUX1 in Model Organisms
External links
- OMIM
- 116896
- Ensembl
- ENSG00000257923
- Entrez Gene
- 1523
- UniGene
- 191482
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CUX1
- GeneCards
- CUX1