Cell Senescence Entries for CXCR2

Cell Types
Lung fibroblast, Mammary epithelial
Cell Lines
IMR-90, Primary cell, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Acosta et al. (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133(6)1006-18 (PubMed)

CXCR2 Gene Information

HGNC symbol
CXCR2 
Aliases
CD182; CMKAR2; IL8RB 
Common name
C-X-C motif chemokine receptor 2 
Entrez Id
3579
Description
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].

CXCR2 Ontologies

Gene Ontology
Process: GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:6935; chemotaxis
GO:70098; chemokine-mediated signaling pathway
GO:7166; cell surface receptor signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:6955; immune response
GO:30593; neutrophil chemotaxis
GO:31623; receptor internalization
GO:6954; inflammatory response
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:19722; calcium-mediated signaling
GO:60326; cell chemotaxis
GO:2407; dendritic cell chemotaxis
GO:7200; phospholipase C-activating G protein-coupled receptor signaling pathway
GO:42119; neutrophil activation
GO:6968; cellular defense response
GO:38112; interleukin-8-mediated signaling pathway
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:15630; microtubule cytoskeleton
GO:72686; mitotic spindle
GO:5654; nucleoplasm
GO:9986; cell surface
GO:9897; external side of plasma membrane
GO:5887; integral component of plasma membrane
GO:30667; secretory granule membrane
GO:42629; mast cell granule
Function: GO:4930; G protein-coupled receptor activity
GO:16494; C-X-C chemokine receptor activity
GO:19959; interleukin-8 binding
GO:5515; protein binding
GO:16493; C-C chemokine receptor activity
GO:19957; C-C chemokine binding
GO:4918; interleukin-8 receptor activity
Hide GO terms

Homologs of CXCR2 in Model Organisms

Danio rerio
LOC796724
Rattus norvegicus
Cxcr2

External links

OMIM
146928
Ensembl
ENSG00000180871
Entrez Gene
3579
UniGene
846
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CXCR2
GeneCards
CXCR2