Cell Senescence Entries for CYB5R3

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown, Mutation
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Siendones et al. (2015) Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2. Antioxid Redox Signal 21(12)1708-25 (PubMed)

CYB5R3 Gene Information

HGNC symbol
CYB5R3 
Aliases
DIA1 
Common name
cytochrome b5 reductase 3 
Entrez Id
1727
Description
This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010].

CYB5R3 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:6809; nitric oxide biosynthetic process
GO:8015; blood circulation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:5576; extracellular region
GO:5811; lipid droplet
GO:35578; azurophil granule lumen
GO:1903958; nitric-oxide synthase complex
GO:5833; hemoglobin complex
Function: GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:71949; FAD binding
GO:4128; cytochrome-b5 reductase activity, acting on NAD(P)H
GO:50421; nitrite reductase (NO-forming) activity
Hide GO terms

Homologs of CYB5R3 in Model Organisms

Danio rerio
cyb5r3
Mus musculus
Cyb5r3
Rattus norvegicus
Cyb5r3
Saccharomyces cerevisiae
AIM33

External links

OMIM
613213
Ensembl
ENSG00000100243
Entrez Gene
1727
UniGene
561064
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CYB5R3
GeneCards
CYB5R3