Cell Senescence Entries for CYBB

Cell Types
Endodthelial progenitor
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Li et al. (2012) Correlation of different NADPH oxidase homologues with late endothelial progenitor cell senescence induced by angiotensin II: effect of telmisartan. Intern Med 50(16)1631-42 (PubMed)

CYBB Gene Information

HGNC symbol
CYBB 
Aliases
CGD; GP91-PHOX; NOX2 
Common name
cytochrome b-245 beta chain 
Entrez Id
1536
Description
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008].

CYBB Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:34220; ion transmembrane transport
GO:34765; regulation of ion transmembrane transport
GO:45087; innate immune response
GO:6954; inflammatory response
GO:22900; electron transport chain
GO:6801; superoxide metabolic process
GO:7584; response to nutrient
GO:9410; response to xenobiotic stimulus
GO:32760; positive regulation of tumor necrosis factor production
GO:45766; positive regulation of angiogenesis
GO:50665; hydrogen peroxide biosynthetic process
GO:71276; cellular response to cadmium ion
GO:71361; cellular response to ethanol
GO:71456; cellular response to hypoxia
GO:72593; reactive oxygen species metabolic process
GO:97411; hypoxia-inducible factor-1alpha signaling pathway
GO:1904044; response to aldosterone
GO:1904845; cellular response to L-glutamine
GO:1990776; response to angiotensin
GO:6952; defense response
GO:42554; superoxide anion generation
GO:45730; respiratory burst
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:5635; nuclear envelope
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5791; rough endoplasmic reticulum
GO:5794; Golgi apparatus
GO:30425; dendrite
GO:43020; NADPH oxidase complex
GO:43025; neuronal cell body
GO:45335; phagocytic vesicle
GO:97038; perinuclear endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:35579; specific granule membrane
GO:70821; tertiary granule membrane
GO:30670; phagocytic vesicle membrane
Function: GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:46872; metal ion binding
GO:5244; voltage-gated ion channel activity
GO:16175; superoxide-generating NAD(P)H oxidase activity
GO:46982; protein heterodimerization activity
GO:20037; heme binding
GO:9055; electron transfer activity
GO:50660; flavin adenine dinucleotide binding
Hide GO terms

Homologs of CYBB in Model Organisms

Danio rerio
cybb
Mus musculus
Cybb
Rattus norvegicus
Cybb

External links

OMIM
300481
Ensembl
ENSG00000165168
Entrez Gene
1536
UniGene
292356
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CYBB
GeneCards
CYBB