The DHX9 gene and its putative association with human ageing

Cell Types

Lung fibroblast

Cell Lines

MRC-5

Cancer Cell?

No

Method

Knockdown

Type of senescence

Replicative

Senescence Effect

Inhibits

Primary Reference

Lee et al. (2014) Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner. J Biol Chem 289(33)22798-22814 (PubMed)

HGNC symbol

DHX9

Aliases

DDX9; LKP; RHA

Common name

DExH-box helicase 9

Entrez Id

1660

Description

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010].

Gene Ontology

Process:

GO:6397; mRNA processing
GO:8380; RNA splicing
GO:51028; mRNA transport
GO:6417; regulation of translation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6260; DNA replication
GO:2376; immune system process
GO:45087; innate immune response
GO:48511; rhythmic process
GO:31047; gene silencing by RNA
GO:6954; inflammatory response
GO:6357; regulation of transcription by RNA polymerase II
GO:45739; positive regulation of DNA repair
GO:32755; positive regulation of interleukin-6 production
GO:32760; positive regulation of tumor necrosis factor production
GO:50729; positive regulation of inflammatory response
GO:2000637; positive regulation of gene silencing by miRNA
GO:71356; cellular response to tumor necrosis factor
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:70934; CRD-mediated mRNA stabilization
GO:10501; RNA secondary structure unwinding
GO:32727; positive regulation of interferon-alpha production
GO:32728; positive regulation of interferon-beta production
GO:1903608; protein localization to cytoplasmic stress granule
GO:45089; positive regulation of innate immune response
GO:6353; DNA-templated transcription, termination
GO:70269; pyroptosis
GO:45740; positive regulation of DNA replication
GO:48146; positive regulation of fibroblast proliferation
GO:2000373; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:1649; osteoblast differentiation
GO:1900152; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000767; positive regulation of cytoplasmic translation
GO:380; alternative mRNA splicing, via spliceosome
GO:71360; cellular response to exogenous dsRNA
GO:60760; positive regulation of response to cytokine stimulus
GO:50684; regulation of mRNA processing
GO:32508; DNA duplex unwinding
GO:46833; positive regulation of RNA export from nucleus
GO:30423; targeting of mRNA for destruction involved in RNA interference
GO:32741; positive regulation of interleukin-18 production
GO:34622; cellular protein-containing complex assembly
GO:39695; DNA-templated viral transcription
GO:44806; G-quadruplex DNA unwinding
GO:50434; positive regulation of viral transcription
GO:50691; regulation of defense response to virus by host
GO:70922; small RNA loading onto RISC
GO:1904973; positive regulation of viral translation
GO:1905698; positive regulation of polysome binding
GO:2000765; regulation of cytoplasmic translation

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5856; cytoskeleton
GO:1990904; ribonucleoprotein complex
GO:36464; cytoplasmic ribonucleoprotein granule
GO:5815; microtubule organizing center
GO:5813; centrosome
GO:16442; RISC complex
GO:5829; cytosol
GO:15629; actin cytoskeleton
GO:16604; nuclear body
GO:70937; CRD-mediated mRNA stability complex
GO:5844; polysome
GO:70578; RISC-loading complex
GO:42788; polysomal ribosome
GO:97165; nuclear stress granule
GO:5726; perichromatin fibrils

Function:

GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3725; double-stranded RNA binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:3724; RNA helicase activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3729; mRNA binding
GO:3678; DNA helicase activity
GO:3713; transcription coactivator activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3690; double-stranded DNA binding
GO:3688; DNA replication origin binding
GO:3697; single-stranded DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:35613; RNA stem-loop binding
GO:3712; transcription coregulator activity
GO:47429; nucleoside-triphosphate diphosphatase activity
GO:1990841; promoter-specific chromatin binding
GO:70063; RNA polymerase binding
GO:17111; nucleoside-triphosphatase activity
GO:43138; 3'-5' DNA helicase activity
GO:993; RNA polymerase II complex binding
GO:3727; single-stranded RNA binding
GO:1990825; sequence-specific mRNA binding
GO:35197; siRNA binding
GO:1069; regulatory region RNA binding
GO:33679; 3'-5' DNA/RNA helicase activity
GO:34458; 3'-5' RNA helicase activity
GO:45142; triplex DNA binding
GO:61676; importin-alpha family protein binding
GO:1905172; RISC complex binding
GO:1905538; polysome binding
GO:1990518; single-stranded 3'-5' DNA helicase activity

Hide GO terms

Caenorhabditis elegans

rha-1

Danio rerio

dhx9

Drosophila melanogaster

mle

Mus musculus

Dhx9

Rattus norvegicus

Dhx9

GenAge model organism genes