Cell Senescence Entries for DLC1

Cell Types
Liver cancer
Cell Lines
HuH6
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Hampl et al. (2014) Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. EMBO Mol Med 5(9)1367-82 (PubMed)

DLC1 Gene Information

HGNC symbol
DLC1 
Aliases
ARHGAP7; DLC-1; HP; p122-RhoGAP; STARD12 
Common name
DLC1 Rho GTPase activating protein 
Entrez Id
10395
Description
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010].

DLC1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:35023; regulation of Rho protein signal transduction
GO:30036; actin cytoskeleton organization
GO:6915; apoptotic process
GO:1843; neural tube closure
GO:8285; negative regulation of cell population proliferation
GO:32956; regulation of actin cytoskeleton organization
GO:51056; regulation of small GTPase mediated signal transduction
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:8360; regulation of cell shape
GO:48041; focal adhesion assembly
GO:51895; negative regulation of focal adhesion assembly
GO:30336; negative regulation of cell migration
GO:3007; heart morphogenesis
GO:51497; negative regulation of stress fiber assembly
GO:30900; forebrain development
GO:1900119; positive regulation of execution phase of apoptosis
GO:35307; positive regulation of protein dephosphorylation
GO:35024; negative regulation of Rho protein signal transduction
GO:21575; hindbrain morphogenesis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5901; caveola
GO:5925; focal adhesion
GO:5829; cytosol
GO:30054; cell junction
GO:32587; ruffle membrane
GO:30864; cortical actin cytoskeleton
GO:45121; membrane raft
Function: GO:5515; protein binding
GO:8289; lipid binding
GO:5096; GTPase activator activity
GO:42169; SH2 domain binding
Hide GO terms

Homologs of DLC1 in Model Organisms

Danio rerio
uncharacterized_E7FB
Mus musculus
Dlc1
Rattus norvegicus
Dlc1

External links

OMIM
604258
Ensembl
ENSG00000164741
Entrez Gene
10395
UniGene
738560
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DLC1
GeneCards
DLC1