Cell Senescence Entries for DNMT3A

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2011) DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. Int J Cancer 128(3)551-61 (PubMed)

DNMT3A Gene Information

HGNC symbol
DNMT3A 
Aliases
 
Common name
DNA methyltransferase 3 alpha 
Entrez Id
1788
Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].

DNMT3A Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:6325; chromatin organization
GO:6349; regulation of gene expression by genetic imprinting
GO:45892; negative regulation of transcription, DNA-templated
GO:6306; DNA methylation
GO:32776; DNA methylation on cytosine
GO:6479; protein methylation
GO:10468; regulation of gene expression
GO:122; negative regulation of transcription by RNA polymerase II
GO:90116; C-5 methylation of cytosine
GO:278; mitotic cell cycle
GO:6346; DNA methylation-dependent heterochromatin assembly
GO:7283; spermatogenesis
GO:7568; aging
GO:9410; response to xenobiotic stimulus
GO:9636; response to toxic substance
GO:10212; response to ionizing radiation
GO:10288; response to lead ion
GO:10942; positive regulation of cell death
GO:30182; neuron differentiation
GO:31667; response to nutrient levels
GO:32355; response to estradiol
GO:33189; response to vitamin A
GO:42220; response to cocaine
GO:43045; DNA methylation involved in embryo development
GO:43046; DNA methylation involved in gamete generation
GO:45471; response to ethanol
GO:71230; cellular response to amino acid stimulus
GO:71361; cellular response to ethanol
GO:71456; cellular response to hypoxia
GO:97284; hepatocyte apoptotic process
GO:1903926; cellular response to bisphenol A
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16363; nuclear matrix
GO:1902494; catalytic complex
GO:791; euchromatin
GO:775; chromosome, centromeric region
GO:792; heterochromatin
GO:1741; XY body
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:3886; DNA (cytosine-5-)-methyltransferase activity
GO:9008; DNA-methyltransferase activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3714; transcription corepressor activity
GO:106363; protein-cysteine methyltransferase activity
GO:3682; chromatin binding
Hide GO terms

Homologs of DNMT3A in Model Organisms

Danio rerio
dnmt3ab
Mus musculus
Dnmt3a
Rattus norvegicus
Dnmt3a

External links

OMIM
602769
Ensembl
ENSG00000119772
Entrez Gene
1788
UniGene
515840
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DNMT3A
GeneCards
DNMT3A