Cell Senescence Entries for DNMT3B

Cell Types
HUCB-MSCs
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
So et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS One 6(5)e19503 (PubMed)

DNMT3B Gene Information

HGNC symbol
DNMT3B 
Aliases
 
Common name
DNA methyltransferase 3 beta 
Entrez Id
1789
Description
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011].

DNMT3B Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:6306; DNA methylation
GO:10468; regulation of gene expression
GO:10628; positive regulation of gene expression
GO:51571; positive regulation of histone H3-K4 methylation
GO:51573; negative regulation of histone H3-K9 methylation
GO:90116; C-5 methylation of cytosine
GO:32776; DNA methylation on cytosine
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:1902494; catalytic complex
Function: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3886; DNA (cytosine-5-)-methyltransferase activity
GO:9008; DNA-methyltransferase activity
GO:3714; transcription corepressor activity
GO:51718; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
Hide GO terms

Homologs of DNMT3B in Model Organisms

Danio rerio
dnmt4
Mus musculus
Dnmt3b
Rattus norvegicus
Dnmt3b

External links

OMIM
602900
Ensembl
ENSG00000088305
Entrez Gene
1789
UniGene
713611
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DNMT3B
GeneCards
DNMT3B