Cell Senescence Entries for DPP4

Cell Types
Embryonic kidney, Fibroblast
Cell Lines
BJ, HEK293T, TIG-3
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Li et al. (2019) LncRNA-OIS1 regulates DPP4 activation to modulate senescence induced by RAS. Nucleic Acids Res 46(8)4213-4227 (PubMed)

DPP4 Gene Information

HGNC symbol
DPP4 
Aliases
ADCP2; CD26; DPPIV 
Common name
dipeptidyl peptidase 4 
Entrez Id
1803
Description
The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020].

DPP4 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:6508; proteolysis
GO:8284; positive regulation of cell population proliferation
GO:1666; response to hypoxia
GO:42110; T cell activation
GO:50919; negative chemotaxis
GO:43542; endothelial cell migration
GO:31295; T cell costimulation
GO:33632; regulation of cell-cell adhesion mediated by integrin
GO:16486; peptide hormone processing
GO:1662; behavioral fear response
GO:10716; negative regulation of extracellular matrix disassembly
GO:35641; locomotory exploration behavior
GO:36343; psychomotor behavior
GO:90024; negative regulation of neutrophil chemotaxis
GO:120116; glucagon processing
GO:46718; viral entry into host cell
GO:46813; receptor-mediated virion attachment to host cell
GO:19065; receptor-mediated endocytosis of virus by host cell
GO:61025; membrane fusion
Cellular component: GO:110165; cellular anatomical entity
GO:5886; plasma membrane
GO:30054; cell junction
GO:42995; cell projection
GO:31258; lamellipodium membrane
GO:16020; membrane
GO:16021; integral component of membrane
GO:5765; lysosomal membrane
GO:5576; extracellular region
GO:5925; focal adhesion
GO:16324; apical plasma membrane
GO:45121; membrane raft
GO:9986; cell surface
GO:30027; lamellipodium
GO:70062; extracellular exosome
GO:30139; endocytic vesicle
GO:46581; intercellular canaliculus
Function: GO:16787; hydrolase activity
GO:4252; serine-type endopeptidase activity
GO:8236; serine-type peptidase activity
GO:8233; peptidase activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:5102; signaling receptor binding
GO:4177; aminopeptidase activity
GO:42802; identical protein binding
GO:8239; dipeptidyl-peptidase activity
GO:2020; protease binding
GO:1618; virus receptor activity
GO:45499; chemorepellent activity
Hide GO terms

Homologs of DPP4 in Model Organisms

Caenorhabditis elegans
dpf-2
Danio rerio
fap
Mus musculus
Dpp4
Rattus norvegicus
Dpp4

In other databases

CellAge gene expression
  • This gene is present as DPP4

External links

OMIM
102720
Ensembl
ENSG00000197635
Entrez Gene
1803
UniGene
368912
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DPP4
GeneCards
DPP4