Cell Senescence Entries for DPY30
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockout
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Simboeck et al. (2013) DPY30 regulates pathways in cellular senescence through ID protein expression. EMBO J 32(16)2217-30 (PubMed)
DPY30 Gene Information
- HGNC symbol
- DPY30
- Aliases
- Cps25; HDPY-30; Saf19
- Common name
- dpy-30 histone methyltransferase complex regulatory subunit
- Entrez Id
- 84661
- Description
- This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016].
DPY30 Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:16197; endosomal transport
GO:51568; histone H3-K4 methylation
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5802; trans-Golgi network
GO:48188; Set1C/COMPASS complex
GO:44666; MLL3/4 complex
GO:44665; MLL1/2 complex
GO:71339; MLL1 complex
GO:35097; histone methyltransferase complex
Hide GO termsFunction: GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:42802; identical protein binding
Homologs of DPY30 in Model Organisms
External links
- OMIM
- 612032
- Ensembl
- ENSG00000162961
- Entrez Gene
- 84661
- UniGene
- 679657
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- DPY30
- GeneCards
- DPY30