Cell Senescence Entries for DTL

Cell Types
Liver cancer
Cell Lines
SK-HEP-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Chen et al. (2022) Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells. Onco Targets Ther 11(2)1601-1616 (PubMed)

DTL Gene Information

HGNC symbol
DTL 
Aliases
CDT2; DCAF2; L2DTL; RAMP 
Common name
denticleless E3 ubiquitin protein ligase homolog 
Entrez Id
51514
Description

DTL Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6974; cellular response to DNA damage stimulus
GO:6260; DNA replication
GO:48511; rhythmic process
GO:6511; ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:51726; regulation of cell cycle
GO:45732; positive regulation of protein catabolic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:9411; response to UV
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:6513; protein monoubiquitination
GO:19985; translesion synthesis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:31965; nuclear membrane
GO:5815; microtubule organizing center
GO:5813; centrosome
GO:31464; Cul4A-RING E3 ubiquitin ligase complex
GO:80008; Cul4-RING E3 ubiquitin ligase complex
GO:31465; Cul4B-RING E3 ubiquitin ligase complex
Function: GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
GO:30674; protein-macromolecule adaptor activity
Hide GO terms

Homologs of DTL in Model Organisms

Danio rerio
dtl
Mus musculus
Dtl
Rattus norvegicus
Dtl

In other databases

CellAge gene expression
  • This gene is present as DTL

External links

OMIM
610617
Ensembl
ENSG00000143476
Entrez Gene
51514
UniGene
656473
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DTL
GeneCards
DTL