Cell Senescence Entries for DUSP21

Cell Types
Hepatocellular carcinoma
Cell Lines
HCC
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Deng et al. (2014) RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma. Hepatology 59(2)518-30 (PubMed)

DUSP21 Gene Information

HGNC symbol
DUSP21 
Aliases
 
Common name
dual specificity phosphatase 21 
Entrez Id
63904
Description
This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009].

DUSP21 Ontologies

Gene Ontology
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5759; mitochondrial matrix
GO:31314; extrinsic component of mitochondrial inner membrane
Function: GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:8138; protein tyrosine/serine/threonine phosphatase activity
GO:17017; MAP kinase tyrosine/serine/threonine phosphatase activity
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Homologs of DUSP21 in Model Organisms

Caenorhabditis elegans
C04F12.8
Drosophila melanogaster
CG15528

External links

OMIM
300678
Ensembl
ENSG00000189037
Entrez Gene
63904
UniGene
534478
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DUSP21
GeneCards
DUSP21