Cell Senescence Entries for DUSP3

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Rahmouni et al. (2006) Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol 8(5)524-31 (PubMed)

DUSP3 Gene Information

HGNC symbol
DUSP3 
Aliases
VHR 
Common name
dual specificity phosphatase 3 
Entrez Id
1845
Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].

DUSP3 Ontologies

Gene Ontology
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:46329; negative regulation of JNK cascade
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:43409; negative regulation of MAPK cascade
GO:30336; negative regulation of cell migration
GO:71364; cellular response to epidermal growth factor stimulus
GO:50860; negative regulation of T cell receptor signaling pathway
GO:45931; positive regulation of mitotic cell cycle
GO:50868; negative regulation of T cell activation
GO:1990264; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:51893; regulation of focal adhesion assembly
GO:120183; positive regulation of focal adhesion disassembly
GO:42059; negative regulation of epidermal growth factor receptor signaling pathway
GO:50922; negative regulation of chemotaxis
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5737; cytoplasm
GO:1772; immunological synapse
Function: GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:8138; protein tyrosine/serine/threonine phosphatase activity
GO:19901; protein kinase binding
GO:8092; cytoskeletal protein binding
GO:30971; receptor tyrosine kinase binding
GO:33549; MAP kinase phosphatase activity
GO:1990782; protein tyrosine kinase binding
Hide GO terms

Homologs of DUSP3 in Model Organisms

Danio rerio
CR932037.1
Mus musculus
Dusp3
Rattus norvegicus
Dusp3

In other databases

CellAge gene expression
  • This gene is present as DUSP3

External links

OMIM
600183
Ensembl
ENSG00000108861
Entrez Gene
1845
UniGene
181046
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DUSP3
GeneCards
DUSP3