Cell Senescence Entries for DUSP6

Cell Types
Thyrocytes
Cell Lines
Primary cell
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2015) TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6. Neoplasia 16(12)1107-20 (PubMed)

DUSP6 Gene Information

HGNC symbol
DUSP6 
Aliases
MKP-3; PYST1 
Common name
dual specificity phosphatase 6 
Entrez Id
1848
Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014].

DUSP6 Ontologies

Gene Ontology
Process: GO:6470; protein dephosphorylation
GO:16311; dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:43065; positive regulation of apoptotic process
GO:1933; negative regulation of protein phosphorylation
GO:9410; response to xenobiotic stimulus
GO:10033; response to organic substance
GO:10942; positive regulation of cell death
GO:14070; response to organic cyclic compound
GO:30154; cell differentiation
GO:60420; regulation of heart growth
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:70848; response to growth factor
GO:43409; negative regulation of MAPK cascade
GO:165; MAPK cascade
GO:70371; ERK1 and ERK2 cascade
GO:51409; response to nitrosative stress
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:16787; hydrolase activity
GO:4722; protein serine/threonine phosphatase activity
GO:4721; phosphoprotein phosphatase activity
GO:106306; protein serine phosphatase activity
GO:106307; protein threonine phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:16791; phosphatase activity
GO:8138; protein tyrosine/serine/threonine phosphatase activity
GO:17017; MAP kinase tyrosine/serine/threonine phosphatase activity
GO:8330; protein tyrosine/threonine phosphatase activity
Hide GO terms

Homologs of DUSP6 in Model Organisms

Danio rerio
dusp6
Mus musculus
Dusp6
Rattus norvegicus
Dusp6

In other databases

LongevityMap
  • This gene is present as DUSP6
CellAge gene expression
  • This gene is present as DUSP6

External links

OMIM
602748
Ensembl
ENSG00000139318
Entrez Gene
1848
UniGene
718640
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DUSP6
GeneCards
DUSP6