Cell Senescence Entries for E2F1

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Dimri et al. (2000) Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 20(1)273-85 (PubMed)

E2F1 Gene Information

HGNC symbol
E2F1 
Aliases
RBBP3; RBP3 
Common name
E2F transcription factor 1 
Entrez Id
1869
Description
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].

E2F1 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:6357; regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:6351; transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:45599; negative regulation of fat cell differentiation
GO:70345; negative regulation of fat cell proliferation
GO:77; DNA damage checkpoint signaling
GO:82; G1/S transition of mitotic cell cycle
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:48146; positive regulation of fibroblast proliferation
GO:43392; negative regulation of DNA binding
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:71930; negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:48255; mRNA stabilization
GO:83; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:7283; spermatogenesis
GO:30900; forebrain development
GO:43276; anoikis
GO:51726; regulation of cell cycle
GO:60252; positive regulation of glial cell proliferation
GO:71398; cellular response to fatty acid
GO:71456; cellular response to hypoxia
GO:71466; cellular response to xenobiotic stimulus
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990086; lens fiber cell apoptotic process
GO:1990090; cellular response to nerve growth factor stimulus
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5813; centrosome
GO:5667; transcription regulator complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:35189; Rb-E2F complex
GO:5737; cytoplasm
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1216; DNA-binding transcription activator activity
GO:976; transcription cis-regulatory region binding
GO:19901; protein kinase binding
Hide GO terms

Homologs of E2F1 in Model Organisms

Danio rerio
uncharacterized_H9GY
Mus musculus
E2f1

In other databases

GenAge human genes
  • This gene is present as E2F1

External links

OMIM
189971
Ensembl
ENSG00000101412
Entrez Gene
1869
UniGene
654393
1000 Genomes
1000 Genomes
HPRD
GenAtlas
E2F1
GeneCards
E2F1