Cell Senescence Entries for EGLN1

Cell Types
Endometrial cancer
Cell Lines
HHUA, HWCA, Ishikawa
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Kato et al. (2006) Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer 118(5)1144-53 (PubMed)

EGLN1 Gene Information

HGNC symbol
EGLN1 
Aliases
C1orf12; HIFPH2; PHD2; SM-20; ZMYND6 
Common name
egl-9 family hypoxia inducible factor 1 
Entrez Id
54583
Description
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009].

EGLN1 Ontologies

Gene Ontology
Process: GO:18401; peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:71456; cellular response to hypoxia
GO:45765; regulation of angiogenesis
GO:71731; response to nitric oxide
GO:1666; response to hypoxia
GO:51344; negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:32364; oxygen homeostasis
GO:43433; negative regulation of DNA-binding transcription factor activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5506; iron ion binding
GO:16705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:31418; L-ascorbic acid binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:8198; ferrous iron binding
GO:31543; peptidyl-proline dioxygenase activity
GO:31545; peptidyl-proline 4-dioxygenase activity
GO:19899; enzyme binding
GO:16706; 2-oxoglutarate-dependent dioxygenase activity
Hide GO terms

Homologs of EGLN1 in Model Organisms

Danio rerio
si:ch1073-423n4.1
Mus musculus
Egln1
Rattus norvegicus
Egln1

External links

OMIM
606425
Ensembl
ENSG00000135766
Entrez Gene
54583
UniGene
444450
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EGLN1
GeneCards
EGLN1