Cell Senescence Entries for EHMT2

Cell Types
Colorectal cancer
Cell Lines
HT29, SW620
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Zhang et al. (2015) Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation. Oncotarget 6(5)2917-27 (PubMed)

EHMT2 Gene Information

HGNC symbol
EHMT2 
Aliases
BAT8; C6orf30; Em:AF134726.3; G9A; KMT1C; NG36/G9a 
Common name
euchromatic histone lysine methyltransferase 2 
Entrez Id
10919
Description
This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

EHMT2 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:34968; histone lysine methylation
GO:32259; methylation
GO:16571; histone methylation
GO:18027; peptidyl-lysine dimethylation
GO:6306; DNA methylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:6275; regulation of DNA replication
GO:9267; cellular response to starvation
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5694; chromosome
GO:785; chromatin
Function: GO:8270; zinc ion binding
GO:2039; p53 binding
GO:18024; histone-lysine N-methyltransferase activity
GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:16279; protein-lysine N-methyltransferase activity
GO:1222; transcription corepressor binding
GO:46974; histone methyltransferase activity (H3-K9 specific)
GO:1990841; promoter-specific chromatin binding
GO:70742; C2H2 zinc finger domain binding
GO:46976; histone methyltransferase activity (H3-K27 specific)
Hide GO terms

Homologs of EHMT2 in Model Organisms

Danio rerio
ehmt2
Mus musculus
Ehmt2
Rattus norvegicus
Ehmt2

External links

OMIM
604599
Ensembl
ENSG00000204371
Entrez Gene
10919
UniGene
709218
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EHMT2
GeneCards
EHMT2