Cell Senescence Entries for EIF2AK2

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Li et al. (2020) Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence. Am J Physiol Heart Circ Physiol 315(3)H571-H580 (PubMed)

EIF2AK2 Gene Information

HGNC symbol
EIF2AK2 
Aliases
EIF2AK1; PKR; PPP1R83; PRKR 
Common name
eukaryotic translation initiation factor 2 alpha kinase 2 
Entrez Id
5610
Description
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021].

EIF2AK2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:50790; regulation of catalytic activity
GO:17148; negative regulation of translation
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:1902036; regulation of hematopoietic stem cell differentiation
GO:46777; protein autophosphorylation
GO:1819; positive regulation of cytokine production
GO:9615; response to virus
GO:45071; negative regulation of viral genome replication
GO:43410; positive regulation of MAPK cascade
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:32874; positive regulation of stress-activated MAPK cascade
GO:8285; negative regulation of cell population proliferation
GO:32722; positive regulation of chemokine production
GO:34198; cellular response to amino acid starvation
GO:35455; response to interferon-alpha
GO:6412; translation
GO:10998; regulation of translational initiation by eIF2 alpha phosphorylation
GO:30968; endoplasmic reticulum unfolded protein response
GO:33689; negative regulation of osteoblast proliferation
GO:43066; negative regulation of apoptotic process
GO:1900225; regulation of NLRP3 inflammasome complex assembly
GO:1901532; regulation of hematopoietic progenitor cell differentiation
GO:1902033; regulation of hematopoietic stem cell proliferation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:5840; ribosome
Function: GO:3723; RNA binding
GO:3725; double-stranded RNA binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:5524; ATP binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:42802; identical protein binding
GO:4694; eukaryotic translation initiation factor 2alpha kinase activity
GO:19888; protein phosphatase regulator activity
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Homologs of EIF2AK2 in Model Organisms

Danio rerio
eif2ak2
Mus musculus
Eif2ak2
Rattus norvegicus
Eif2ak2

External links

OMIM
176871
Ensembl
ENSG00000055332
Entrez Gene
5610
UniGene
131431
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EIF2AK2
GeneCards
EIF2AK2