The EIF2AK3 gene and its putative association with human ageing

Cell Senescence Entries for EIF2AK3

Cell Types: Breast cancer
Cell Lines: MCF-7
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Kim et al. (2012) Phenylbutyric acid induces the cellular senescence through an Akt/p21(WAF1) signaling pathway. Biochem Biophys Res Commun 422(2)213-8 (PubMed)

EIF2AK3 Gene Information

HGNC symbol: EIF2AK3
Aliases: PEK; PERK
Common name: eukaryotic translation initiation factor 2 alpha kinase 3
Entrez Id: 9451
Description: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].

EIF2AK3 Ontologies

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6417; regulation of translation
GO:17148; negative regulation of translation
GO:6986; response to unfolded protein
GO:2063; chondrocyte development
GO:1503; ossification
GO:46777; protein autophosphorylation
GO:1501; skeletal system development
GO:30282; bone mineralization
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:19722; calcium-mediated signaling
GO:7029; endoplasmic reticulum organization
GO:34976; response to endoplasmic reticulum stress
GO:31642; negative regulation of myelination
GO:10628; positive regulation of gene expression
GO:34198; cellular response to amino acid starvation
GO:18105; peptidyl-serine phosphorylation
GO:30968; endoplasmic reticulum unfolded protein response
GO:48009; insulin-like growth factor receptor signaling pathway
GO:32057; negative regulation of translational initiation in response to stress
GO:36499; PERK-mediated unfolded protein response
GO:10575; positive regulation of vascular endothelial growth factor production
GO:42149; cellular response to glucose starvation
GO:45943; positive regulation of transcription by RNA polymerase I
GO:31018; endocrine pancreas development
GO:70417; cellular response to cold
GO:1900182; positive regulation of protein localization to nucleus
GO:1525; angiogenesis
GO:6983; ER overload response
GO:10998; regulation of translational initiation by eIF2 alpha phosphorylation
GO:32055; negative regulation of translation in response to stress
GO:36492; eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:60734; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1902235; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990737; response to manganese-induced endoplasmic reticulum stress

Cellular component:

GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:30176; integral component of endoplasmic reticulum membrane
GO:48471; perinuclear region of cytoplasm

Function:

GO:5524; ATP binding
GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:19903; protein phosphatase binding
GO:4694; eukaryotic translation initiation factor 2alpha kinase activity
GO:51879; Hsp90 protein binding

Hide GO terms

Homologs of EIF2AK3 in Model Organisms

Caenorhabditis elegans: pek-1
Danio rerio: eif2ak3
Drosophila melanogaster: PEK
Mus musculus: Eif2ak3
Rattus norvegicus: Eif2ak3

Cell Senescence Entries for EIF2AK3

EIF2AK3 Gene Information

EIF2AK3 Ontologies

Homologs of EIF2AK3 in Model Organisms

External links