Cell Senescence Entries for EIF4E

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Primary Reference
Chao et al. (2011) Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence. Oncotarget 2(1-2)89-98 (PubMed)

EIF4E Gene Information

HGNC symbol
EIF4E 
Aliases
EIF4E1; EIF4EL1; EIF4F 
Common name
eukaryotic translation initiation factor 4E 
Entrez Id
1977
Description
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

EIF4E Ontologies

Gene Ontology
Process: GO:6412; translation
GO:6413; translational initiation
GO:6417; regulation of translation
GO:82; G1/S transition of mitotic cell cycle
GO:45931; positive regulation of mitotic cell cycle
GO:1662; behavioral fear response
GO:17148; negative regulation of translation
GO:19827; stem cell population maintenance
GO:45665; negative regulation of neuron differentiation
GO:71549; cellular response to dexamethasone stimulus
GO:99578; regulation of translation at postsynapse, modulating synaptic transmission
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:36464; cytoplasmic ribonucleoprotein granule
GO:48471; perinuclear region of cytoplasm
GO:932; P-body
GO:10494; cytoplasmic stress granule
GO:98794; postsynapse
GO:70062; extracellular exosome
GO:5845; mRNA cap binding complex
GO:16281; eukaryotic translation initiation factor 4F complex
GO:16442; RISC complex
GO:33391; chromatoid body
GO:98978; glutamatergic synapse
Function: GO:3723; RNA binding
GO:3743; translation initiation factor activity
GO:5515; protein binding
GO:340; RNA 7-methylguanosine cap binding
GO:19899; enzyme binding
GO:31370; eukaryotic initiation factor 4G binding
GO:140297; DNA-binding transcription factor binding
GO:339; RNA cap binding
GO:45182; translation regulator activity
Hide GO terms

Homologs of EIF4E in Model Organisms

Danio rerio
eif4eb
Mus musculus
Eif4e
Rattus norvegicus
Eif4e

In other databases

LongevityMap
  • This gene is present as EIF4E

External links

OMIM
133440
Ensembl
ENSG00000151247
Entrez Gene
1977
UniGene
249718
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EIF4E
GeneCards
EIF4E