Cell Senescence Entries for ELAVL1

ELAVL1 Gene Information

HGNC symbol
ELAVL1 
Aliases
Hua; HUR; MelG 
Common name
ELAV like RNA binding protein 1 
Entrez Id
1994
Description
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].

ELAVL1 Ontologies

Gene Ontology
Process: GO:60965; negative regulation of gene silencing by miRNA
GO:2000036; regulation of stem cell population maintenance
GO:51260; protein homooligomerization
GO:70935; 3'-UTR-mediated mRNA stabilization
GO:48255; mRNA stabilization
GO:45727; positive regulation of translation
GO:6606; protein import into nucleus
GO:16441; posttranscriptional gene silencing
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5654; nucleoplasm
GO:1990904; ribonucleoprotein complex
GO:10494; cytoplasmic stress granule
GO:5783; endoplasmic reticulum
GO:31410; cytoplasmic vesicle
GO:98794; postsynapse
GO:98978; glutamatergic synapse
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:35925; mRNA 3'-UTR AU-rich region binding
GO:19901; protein kinase binding
GO:3730; mRNA 3'-UTR binding
GO:3725; double-stranded RNA binding
GO:3729; mRNA binding
GO:35198; miRNA binding
Hide GO terms

Homologs of ELAVL1 in Model Organisms

Caenorhabditis elegans
exc-7
Danio rerio
elavl1
Drosophila melanogaster
fne
Mus musculus
Elavl1
Rattus norvegicus
Elavl1

External links

OMIM
603466
Ensembl
ENSG00000066044
Entrez Gene
1994
UniGene
713744
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ELAVL1
GeneCards
ELAVL1