Cell Senescence Entries for ENG

Cell Types
Peritoneal mesothelial
Cell Lines
HMR-SV5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Miao et al. (2016) Endoglin overexpression mediates gastric cancer peritoneal dissemination by inducing mesothelial cell senescence. Hum Pathol 51(2)114-23 (PubMed)

ENG Gene Information

HGNC symbol
ENG 
Aliases
CD105; END; HHT1; ORW; ORW1 
Common name
endoglin 
Entrez Id
2022
Description
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].

ENG Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:1525; angiogenesis
GO:1569; branching involved in blood vessel morphogenesis
GO:1570; vasculogenesis
GO:1934; positive regulation of protein phosphorylation
GO:1947; heart looping
GO:3148; outflow tract septum morphogenesis
GO:3198; epithelial to mesenchymal transition involved in endocardial cushion formation
GO:3203; endocardial cushion morphogenesis
GO:3208; cardiac ventricle morphogenesis
GO:3209; cardiac atrium morphogenesis
GO:3222; ventricular trabecula myocardium morphogenesis
GO:3273; cell migration involved in endocardial cushion formation
GO:7507; heart development
GO:9410; response to xenobiotic stimulus
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:17015; regulation of transforming growth factor beta receptor signaling pathway
GO:31960; response to corticosteroid
GO:32967; positive regulation of collagen biosynthetic process
GO:35912; dorsal aorta morphogenesis
GO:45766; positive regulation of angiogenesis
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48745; smooth muscle tissue development
GO:48844; artery morphogenesis
GO:48845; venous blood vessel morphogenesis
GO:55009; atrial cardiac muscle tissue morphogenesis
GO:60348; bone development
GO:70278; extracellular matrix constituent secretion
GO:71260; cellular response to mechanical stimulus
GO:71559; response to transforming growth factor beta
GO:97084; vascular associated smooth muscle cell development
GO:1905007; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905065; positive regulation of vascular associated smooth muscle cell differentiation
GO:1905222; atrioventricular canal morphogenesis
GO:16477; cell migration
GO:1837; epithelial to mesenchymal transition
GO:7179; transforming growth factor beta receptor signaling pathway
GO:51897; positive regulation of protein kinase B signaling
GO:30509; BMP signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:30513; positive regulation of BMP signaling pathway
GO:30336; negative regulation of cell migration
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:60394; negative regulation of pathway-restricted SMAD protein phosphorylation
GO:42060; wound healing
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:22617; extracellular matrix disassembly
GO:42127; regulation of cell population proliferation
GO:60326; cell chemotaxis
GO:1666; response to hypoxia
GO:70483; detection of hypoxia
GO:6355; regulation of transcription, DNA-templated
GO:48870; cell motility
GO:22009; central nervous system vasculogenesis
GO:31953; negative regulation of protein autophosphorylation
GO:30155; regulation of cell adhesion
GO:42325; regulation of phosphorylation
GO:1937; negative regulation of endothelial cell proliferation
GO:3084; positive regulation of systemic arterial blood pressure
GO:51001; negative regulation of nitric-oxide synthase activity
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:16604; nuclear body
GO:5615; extracellular space
GO:5925; focal adhesion
GO:9986; cell surface
GO:72563; endothelial microparticle
GO:9897; external side of plasma membrane
GO:43235; receptor complex
Function: GO:5515; protein binding
GO:5114; type II transforming growth factor beta receptor binding
GO:42803; protein homodimerization activity
GO:50431; transforming growth factor beta binding
GO:42802; identical protein binding
GO:5024; transforming growth factor beta-activated receptor activity
GO:5539; glycosaminoglycan binding
GO:15026; coreceptor activity
GO:34713; type I transforming growth factor beta receptor binding
GO:48185; activin binding
GO:36122; BMP binding
GO:4888; transmembrane signaling receptor activity
GO:5534; galactose binding
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Homologs of ENG in Model Organisms

Mus musculus
Eng
Rattus norvegicus
Eng

External links

OMIM
131195
Ensembl
ENSG00000106991
Entrez Gene
2022
UniGene
76753
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ENG
GeneCards
ENG