Cell Senescence Entries for ENO1

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ghosh et al. (2008) Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence. PLoS One 3(10)e3384 (PubMed)

ENO1 Gene Information

HGNC symbol
ENO1 
Aliases
ENO1L1; MBP-1; MPB1; PPH 
Common name
enolase 1 
Entrez Id
2023
Description
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011].

ENO1 Ontologies

Gene Ontology
Process: GO:6096; glycolytic process
GO:45892; negative regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:30308; negative regulation of cell growth
GO:9615; response to virus
GO:10756; positive regulation of plasminogen activation
GO:45933; positive regulation of muscle contraction
GO:61621; canonical glycolysis
GO:1903298; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:2001171; positive regulation of ATP biosynthetic process
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5615; extracellular space
GO:15; phosphopyruvate hydratase complex
GO:5640; nuclear outer membrane
GO:70062; extracellular exosome
GO:31430; M band
GO:5938; cell cortex
GO:9986; cell surface
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:46872; metal ion binding
GO:287; magnesium ion binding
GO:3677; DNA binding
GO:16829; lyase activity
GO:4634; phosphopyruvate hydratase activity
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:45296; cadherin binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:3714; transcription corepressor activity
GO:1222; transcription corepressor binding
GO:51020; GTPase binding
GO:42803; protein homodimerization activity
Hide GO terms

Homologs of ENO1 in Model Organisms

Danio rerio
eno1a
Mus musculus
Eno1
Rattus norvegicus
uncharacterized_M0R5
Saccharomyces cerevisiae
ERR3

In other databases

CellAge gene expression
  • This gene is present as ENO1

External links

OMIM
172430
Ensembl
ENSG00000074800
Entrez Gene
2023
UniGene
517145
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ENO1
GeneCards
ENO1