The EP300 gene and its putative association with human ageing

Cell Types

Lung fibroblast

Cell Lines

IMR-90

Cancer Cell?

No

Method

Knockdown

Type of senescence

Oncogene-induced, Replicative

Senescence Effect

Induces

Primary Reference

Sen et al. (2019) Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell 73(4)684-698.e8 (PubMed)

HGNC symbol

EP300

Aliases

KAT3B; p300

Common name

E1A binding protein p300

Entrez Id

2033

Description

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:16573; histone acetylation
GO:6473; protein acetylation
GO:45444; fat cell differentiation
GO:31648; protein destabilization
GO:50821; protein stabilization
GO:45721; negative regulation of gluconeogenesis
GO:1666; response to hypoxia
GO:1901796; regulation of signal transduction by p53 class mediator
GO:7399; nervous system development
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:43967; histone H4 acetylation
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:10821; regulation of mitochondrion organization
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:45815; positive regulation of gene expression, epigenetic
GO:43627; response to estrogen
GO:2223; stimulatory C-type lectin receptor signaling pathway
GO:34644; cellular response to UV
GO:6110; regulation of glycolytic process
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1905636; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:6990; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:1900034; regulation of cellular response to heat
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:18393; internal peptidyl-lysine acetylation
GO:31333; negative regulation of protein-containing complex assembly
GO:10976; positive regulation of neuron projection development
GO:10506; regulation of autophagy
GO:10742; macrophage derived foam cell differentiation
GO:43923; positive regulation by host of viral transcription
GO:1756; somitogenesis
GO:1966; thigmotaxis
GO:2209; behavioral defense response
GO:6357; regulation of transcription by RNA polymerase II
GO:6475; internal protein amino acid acetylation
GO:7507; heart development
GO:7519; skeletal muscle tissue development
GO:7611; learning or memory
GO:9887; animal organ morphogenesis
GO:10628; positive regulation of gene expression
GO:18076; N-terminal peptidyl-lysine acetylation
GO:18394; peptidyl-lysine acetylation
GO:30183; B cell differentiation
GO:30220; platelet formation
GO:30324; lung development
GO:32092; positive regulation of protein binding
GO:35264; multicellular organism growth
GO:35855; megakaryocyte development
GO:36268; swimming
GO:43969; histone H2B acetylation
GO:60325; face morphogenesis
GO:60765; regulation of androgen receptor signaling pathway
GO:61921; peptidyl-lysine propionylation
GO:90043; regulation of tubulin deacetylation
GO:97043; histone H3-K56 acetylation
GO:140066; peptidyl-lysine crotonylation
GO:140067; peptidyl-lysine butyrylation
GO:6325; chromatin organization
GO:42221; response to chemical

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:123; histone acetyltransferase complex
GO:5667; transcription regulator complex
GO:32993; protein-DNA complex
GO:32991; protein-containing complex

Function:

GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3713; transcription coactivator activity
GO:3677; DNA binding
GO:3712; transcription coregulator activity
GO:16746; acyltransferase activity
GO:5515; protein binding
GO:4402; histone acetyltransferase activity
GO:3684; damaged DNA binding
GO:140297; DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:31490; chromatin DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:1221; transcription coregulator binding
GO:48156; tau protein binding
GO:10485; H4 histone acetyltransferase activity
GO:8013; beta-catenin binding
GO:16922; nuclear receptor binding
GO:50681; androgen receptor binding
GO:1223; transcription coactivator binding
GO:8022; protein C-terminus binding
GO:16407; acetyltransferase activity
GO:97677; STAT family protein binding
GO:2039; p53 binding
GO:4468; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:10484; H3 histone acetyltransferase activity
GO:34212; peptide N-acetyltransferase activity
GO:51059; NF-kappaB binding
GO:61733; peptide-lysine-N-acetyltransferase activity
GO:61920; protein propionyltransferase activity
GO:97157; pre-mRNA intronic binding
GO:106226; peptide 2-hydroxyisobutyryltransferase activity
GO:120300; peptide lactyltransferase activity
GO:120301; histone lactyltransferase activity
GO:140065; peptide butyryltransferase activity
GO:140068; histone crotonyltransferase activity
GO:140069; histone butyryltransferase activity

Hide GO terms

Danio rerio

ep300a

Mus musculus

Ep300

GenAge human genes