Cell Senescence Entries for EPAS1

Cell Types
Bone marrow neuroblastoma
Cell Lines
SH-SY5Y, SK-N-BE(2)
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Cimmino et al. (2016) Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep 5(2)11158 (PubMed)

EPAS1 Gene Information

HGNC symbol
EPAS1 
Aliases
bHLHe73; HIF2A; HLF; MOP2; PASD2 
Common name
endothelial PAS domain protein 1 
Entrez Id
2034
Description
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. [provided by RefSeq, Nov 2009].

EPAS1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:1525; angiogenesis
GO:6357; regulation of transcription by RNA polymerase II
GO:71456; cellular response to hypoxia
GO:7165; signal transduction
GO:120162; positive regulation of cold-induced thermogenesis
GO:1666; response to hypoxia
GO:2000434; regulation of protein neddylation
GO:1892; embryonic placenta development
GO:1974; blood vessel remodeling
GO:2027; regulation of heart rate
GO:6979; response to oxidative stress
GO:7005; mitochondrion organization
GO:7601; visual perception
GO:10467; gene expression
GO:30097; hemopoiesis
GO:30218; erythrocyte differentiation
GO:30324; lung development
GO:42415; norepinephrine metabolic process
GO:42789; mRNA transcription by RNA polymerase II
GO:43129; surfactant homeostasis
GO:43619; regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:48469; cell maturation
GO:48625; myoblast fate commitment
GO:55072; iron ion homeostasis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5667; transcription regulator complex
GO:16607; nuclear speck
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:46982; protein heterodimerization activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:43565; sequence-specific DNA binding
GO:1223; transcription coactivator binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Hide GO terms

Homologs of EPAS1 in Model Organisms

Danio rerio
epas1b
Mus musculus
Epas1
Rattus norvegicus
Epas1

In other databases

CellAge gene expression
  • This gene is present as EPAS1

External links

OMIM
603349
Ensembl
ENSG00000116016
Entrez Gene
2034
UniGene
468410
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EPAS1
GeneCards
EPAS1