Cell Senescence Entries for EPHA3

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

EPHA3 Gene Information

HGNC symbol
EPHA3 
Aliases
ETK; ETK1; HEK; HEK4; TYRO4 
Common name
EPH receptor A3 
Entrez Id
2042
Description
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].

EPHA3 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7155; cell adhesion
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:18108; peptidyl-tyrosine phosphorylation
GO:48013; ephrin receptor signaling pathway
GO:70507; regulation of microtubule cytoskeleton organization
GO:32956; regulation of actin cytoskeleton organization
GO:16477; cell migration
GO:10717; regulation of epithelial to mesenchymal transition
GO:43087; regulation of GTPase activity
GO:7411; axon guidance
GO:33674; positive regulation of kinase activity
GO:51893; regulation of focal adhesion assembly
GO:1903078; positive regulation of protein localization to plasma membrane
GO:10976; positive regulation of neuron projection development
GO:71300; cellular response to retinoic acid
GO:45806; negative regulation of endocytosis
GO:97155; fasciculation of sensory neuron axon
GO:97156; fasciculation of motor neuron axon
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:5576; extracellular region
GO:31965; nuclear membrane
GO:15629; actin cytoskeleton
GO:5769; early endosome
GO:43005; neuron projection
GO:43235; receptor complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5003; ephrin receptor activity
GO:5515; protein binding
GO:5005; transmembrane-ephrin receptor activity
GO:5004; GPI-linked ephrin receptor activity
Hide GO terms

Homologs of EPHA3 in Model Organisms

Mus musculus
Epha3
Rattus norvegicus
Epha3

External links

OMIM
179611
Ensembl
ENSG00000044524
Entrez Gene
2042
UniGene
123642
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EPHA3
GeneCards
EPHA3