Cell Senescence Entries for EPHA5

Cell Types
Lung cancer
Cell Lines
H1299
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Staquicini et al. (2015) Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer. J Biol Chem 290(12)7345-59 (PubMed)

EPHA5 Gene Information

HGNC symbol
EPHA5 
Aliases
CEK7; EHK1; Hek7; TYRO4 
Common name
EPH receptor A5 
Entrez Id
2044
Description
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013].

EPHA5 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:18108; peptidyl-tyrosine phosphorylation
GO:7399; nervous system development
GO:48013; ephrin receptor signaling pathway
GO:48666; neuron development
GO:32956; regulation of actin cytoskeleton organization
GO:43087; regulation of GTPase activity
GO:19933; cAMP-mediated signaling
GO:7411; axon guidance
GO:33674; positive regulation of kinase activity
GO:32793; positive regulation of CREB transcription factor activity
GO:61178; regulation of insulin secretion involved in cellular response to glucose stimulus
GO:21766; hippocampus development
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:5791; rough endoplasmic reticulum
GO:42995; cell projection
GO:30425; dendrite
GO:48471; perinuclear region of cytoplasm
GO:30424; axon
GO:43005; neuron projection
GO:43235; receptor complex
GO:9897; external side of plasma membrane
GO:43025; neuronal cell body
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5003; ephrin receptor activity
GO:5005; transmembrane-ephrin receptor activity
GO:5004; GPI-linked ephrin receptor activity
GO:5515; protein binding
Hide GO terms

Homologs of EPHA5 in Model Organisms

Danio rerio
CT990561.1
Mus musculus
Epha5
Rattus norvegicus
Epha5

External links

OMIM
600004
Ensembl
ENSG00000145242
Entrez Gene
2044
UniGene
654492
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EPHA5
GeneCards
EPHA5