Cell Senescence Entries for ERCC1

Cell Types
Chondrocyte
Cell Lines
NHAC-kn
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Takayama et al. (2014) Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res 32(10)1326-32 (PubMed)

ERCC1 Gene Information

HGNC symbol
ERCC1 
Aliases
RAD10 
Common name
ERCC excision repair 1, endonuclease non-catalytic subunit 
Entrez Id
2067
Description
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009].

ERCC1 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:720; pyrimidine dimer repair by nucleotide-excision repair
GO:6289; nucleotide-excision repair
GO:6302; double-strand break repair
GO:6310; DNA recombination
GO:6949; syncytium formation
GO:7281; germ cell development
GO:7283; spermatogenesis
GO:7584; response to nutrient
GO:8283; cell population proliferation
GO:8584; male gonad development
GO:9650; UV protection
GO:9744; response to sucrose
GO:10165; response to X-ray
GO:10259; multicellular organism aging
GO:35166; post-embryonic hemopoiesis
GO:35264; multicellular organism growth
GO:35902; response to immobilization stress
GO:36297; interstrand cross-link repair
GO:45190; isotype switching
GO:46686; response to cadmium ion
GO:48468; cell development
GO:48477; oogenesis
GO:48568; embryonic organ development
GO:51276; chromosome organization
GO:60261; positive regulation of transcription initiation from RNA polymerase II promoter
GO:90399; replicative senescence
GO:90656; t-circle formation
GO:1904431; positive regulation of t-circle formation
GO:6979; response to oxidative stress
GO:710; meiotic mismatch repair
GO:6295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:6296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:6303; double-strand break repair via nonhomologous end joining
GO:6312; mitotic recombination
GO:32205; negative regulation of telomere maintenance
GO:61819; telomeric DNA-containing double minutes formation
GO:70914; UV-damage excision repair
GO:1905765; negative regulation of protection from non-homologous end joining at telomere
GO:33683; nucleotide-excision repair, DNA incision
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:781; chromosome, telomeric region
GO:109; nucleotide-excision repair complex
GO:110; nucleotide-excision repair factor 1 complex
GO:70522; ERCC4-ERCC1 complex
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:1094; TFIID-class transcription factor complex binding
GO:3684; damaged DNA binding
GO:4518; nuclease activity
GO:1990841; promoter-specific chromatin binding
GO:4519; endonuclease activity
GO:19904; protein domain specific binding
GO:8022; protein C-terminus binding
GO:3697; single-stranded DNA binding
GO:14; single-stranded DNA endodeoxyribonuclease activity
GO:1990599; 3' overhang single-stranded DNA endodeoxyribonuclease activity
Hide GO terms

Homologs of ERCC1 in Model Organisms

Caenorhabditis elegans
ercc-1
Danio rerio
ercc1
Drosophila melanogaster
Ercc1
Mus musculus
Ercc1
Rattus norvegicus
Ercc1
Schizosaccharomyces pombe
swi10

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ercc1
GenAge human genes
  • This gene is present as ERCC1
LongevityMap
  • This gene is present as ERCC1

External links

OMIM
126380
Ensembl
ENSG00000012061
Entrez Gene
2067
UniGene
710495
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ERCC1
GeneCards
ERCC1