Cell Senescence Entries for ERRFI1

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Milewska et al. (2015) Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation. Cell Signal 26(9)1870-7 (PubMed)

ERRFI1 Gene Information

HGNC symbol
ERRFI1 
Aliases
GENE-33; MIG-6; RALT 
Common name
ERBB receptor feedback inhibitor 1 
Entrez Id
54206
Description
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008].

ERRFI1 Ontologies

Gene Ontology
Process: GO:7175; negative regulation of epidermal growth factor-activated receptor activity
GO:32691; negative regulation of interleukin-1 beta production
GO:32720; negative regulation of tumor necrosis factor production
GO:32869; cellular response to insulin stimulus
GO:32966; negative regulation of collagen biosynthetic process
GO:36120; cellular response to platelet-derived growth factor stimulus
GO:42059; negative regulation of epidermal growth factor receptor signaling pathway
GO:43589; skin morphogenesis
GO:45616; regulation of keratinocyte differentiation
GO:48286; lung alveolus development
GO:50732; negative regulation of peptidyl-tyrosine phosphorylation
GO:60426; lung vasculature development
GO:60428; lung epithelium development
GO:61469; regulation of type B pancreatic cell proliferation
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:71364; cellular response to epidermal growth factor stimulus
GO:71474; cellular hyperosmotic response
GO:71549; cellular response to dexamethasone stimulus
GO:1903243; negative regulation of cardiac muscle hypertrophy in response to stress
GO:31953; negative regulation of protein autophosphorylation
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:17124; SH3 domain binding
GO:19900; kinase binding
GO:31267; small GTPase binding
GO:5096; GTPase activator activity
Hide GO terms

Homologs of ERRFI1 in Model Organisms

Danio rerio
errfi1
Mus musculus
Errfi1
Rattus norvegicus
Errfi1

External links

OMIM
608069
Ensembl
ENSG00000116285
Entrez Gene
54206
UniGene
605445
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ERRFI1
GeneCards
ERRFI1