Cell Senescence Entries for ESPL1

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

ESPL1 Gene Information

HGNC symbol
ESPL1 
Aliases
ESP1; KIAA0165; SEPA 
Common name
extra spindle pole bodies like 1, separase 
Entrez Id
9700
Description
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].

ESPL1 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:6915; apoptotic process
GO:7059; chromosome segregation
GO:281; mitotic cytokinesis
GO:70; mitotic sister chromatid segregation
GO:45842; positive regulation of mitotic metaphase/anaphase transition
GO:212; meiotic spindle organization
GO:278; mitotic cell cycle
GO:7127; meiosis I
GO:40001; establishment of mitotic spindle localization
GO:45143; homologous chromosome segregation
GO:45875; negative regulation of sister chromatid cohesion
GO:51307; meiotic chromosome separation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5813; centrosome
GO:5829; cytosol
GO:72686; mitotic spindle
Function: GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:4197; cysteine-type endopeptidase activity
GO:5515; protein binding
Hide GO terms

Homologs of ESPL1 in Model Organisms

Danio rerio
espl1
Mus musculus
Espl1
Rattus norvegicus
Espl1

In other databases

CellAge gene expression
  • This gene is present as ESPL1

External links

OMIM
604143
Ensembl
ENSG00000135476
Entrez Gene
9700
UniGene
153479
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ESPL1
GeneCards
ESPL1