The ESR1 gene and its putative association with human ageing

Cell Types

Mammary epithelial

Cell Lines

MCF-10A, Primary cell

Cancer Cell?

No

Method

Knockdown, Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Inhibits

Primary Reference

Liu et al. (2018) Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells. Oncotarget 7(26)39097-39107 (PubMed)

HGNC symbol

ESR1

Aliases

ER-alpha; Era; ESR; NR3A1

Common name

estrogen receptor 1

Entrez Id

2099

Description

This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:43401; steroid hormone mediated signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30522; intracellular receptor signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:10629; negative regulation of gene expression
GO:6338; chromatin remodeling
GO:6367; transcription initiation from RNA polymerase II promoter
GO:6357; regulation of transcription by RNA polymerase II
GO:7165; signal transduction
GO:122; negative regulation of transcription by RNA polymerase II
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:30518; intracellular steroid hormone receptor signaling pathway
GO:30520; intracellular estrogen receptor signaling pathway
GO:32355; response to estradiol
GO:43627; response to estrogen
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:71392; cellular response to estradiol stimulus
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:10863; positive regulation of phospholipase C activity
GO:7200; phospholipase C-activating G protein-coupled receptor signaling pathway
GO:45899; positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:71168; protein localization to chromatin
GO:1547; antral ovarian follicle growth
GO:2064; epithelial cell development
GO:8209; androgen metabolic process
GO:8584; male gonad development
GO:34121; regulation of toll-like receptor signaling pathway
GO:42981; regulation of apoptotic process
GO:48146; positive regulation of fibroblast proliferation
GO:48863; stem cell differentiation
GO:50727; regulation of inflammatory response
GO:60065; uterus development
GO:60068; vagina development
GO:60523; prostate epithelial cord elongation
GO:60527; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:60687; regulation of branching involved in prostate gland morphogenesis
GO:60745; mammary gland branching involved in pregnancy
GO:60749; mammary gland alveolus development
GO:60750; epithelial cell proliferation involved in mammary gland duct elongation
GO:71391; cellular response to estrogen stimulus

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5654; nucleoplasm
GO:785; chromatin
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:35327; transcriptionally active chromatin
GO:97550; transcription preinitiation complex

Function:

GO:3677; DNA binding
GO:5496; steroid binding
GO:30284; estrogen receptor activity
GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:8289; lipid binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3707; steroid hormone receptor activity
GO:4879; nuclear receptor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:1221; transcription coregulator binding
GO:8013; beta-catenin binding
GO:34056; estrogen response element binding
GO:1222; transcription corepressor binding
GO:1223; transcription coactivator binding
GO:30235; nitric-oxide synthase regulator activity
GO:1093; TFIIB-class transcription factor binding
GO:17025; TBP-class protein binding
GO:30331; estrogen receptor binding
GO:51117; ATPase binding

Hide GO terms

Danio rerio

esr1

Mus musculus

Esr1

Rattus norvegicus

Esr1

GenAge human genes