Cell Senescence Entries for ETS2

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
HS68, TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Ohtani et al. (2001) Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409(6823)1067-70 (PubMed)

ETS2 Gene Information

HGNC symbol
ETS2 
Aliases
 
Common name
ETS proto-oncogene 2, transcription factor 
Entrez Id
2114
Description
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

ETS2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1501; skeletal system development
GO:1712; ectodermal cell fate commitment
GO:7498; mesoderm development
GO:90009; primitive streak formation
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:19904; protein domain specific binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
Hide GO terms

Homologs of ETS2 in Model Organisms

Danio rerio
ets2
Drosophila melanogaster
pnt
Mus musculus
Ets2
Rattus norvegicus
Ets2

External links

OMIM
164740
Ensembl
ENSG00000157557
Entrez Gene
2114
UniGene
644231
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ETS2
GeneCards
ETS2