Cell Senescence Entries for EWSR1

Cell Types
Hematopoietic stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Cho et al. (2011) Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood 117(4)1156-66 (PubMed)

EWSR1 Gene Information

HGNC symbol
EWSR1 
Aliases
EWS 
Common name
EWS RNA binding protein 1 
Entrez Id
2130
Description
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009].

EWSR1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5886; plasma membrane
GO:15030; Cajal body
Function: GO:3723; RNA binding
GO:3676; nucleic acid binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:5516; calmodulin binding
GO:3712; transcription coregulator activity
Hide GO terms

Homologs of EWSR1 in Model Organisms

Danio rerio
ewsr1b
Mus musculus
Ewsr1
Rattus norvegicus
Ewsr1

In other databases

CellAge gene expression
  • This gene is present as EWSR1

External links

OMIM
133450
Ensembl
ENSG00000182944
Entrez Gene
2130
UniGene
374477
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EWSR1
GeneCards
EWSR1