Cell Senescence Entries for EZH2

Cell Types
Gastric cancer
Cell Lines
SGC-7901
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Bai et al. (2014) Inhibiting enhancer of zeste homolog 2 promotes cellular senescence in gastric cancer cells SGC-7901 by activation of p21 and p16. DNA Cell Biol 33(6)337-44 (PubMed)

EZH2 Gene Information

HGNC symbol
EZH2 
Aliases
ENX-1; EZH1; KMT6; KMT6A 
Common name
enhancer of zeste 2 polycomb repressive complex 2 subunit 
Entrez Id
2146
Description
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].

EZH2 Ontologies

Gene Ontology
Process: GO:6338; chromatin remodeling
GO:34968; histone lysine methylation
GO:32259; methylation
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:48511; rhythmic process
GO:1932; regulation of protein phosphorylation
GO:6306; DNA methylation
GO:6357; regulation of transcription by RNA polymerase II
GO:10468; regulation of gene expression
GO:10629; negative regulation of gene expression
GO:14013; regulation of gliogenesis
GO:14834; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:14898; cardiac muscle hypertrophy in response to stress
GO:16571; histone methylation
GO:21695; cerebellar cortex development
GO:21766; hippocampus development
GO:30183; B cell differentiation
GO:32355; response to estradiol
GO:34244; negative regulation of transcription elongation from RNA polymerase II promoter
GO:35984; cellular response to trichostatin A
GO:36333; hepatocyte homeostasis
GO:42127; regulation of cell population proliferation
GO:42752; regulation of circadian rhythm
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:45605; negative regulation of epidermal cell differentiation
GO:48468; cell development
GO:50767; regulation of neurogenesis
GO:51154; negative regulation of striated muscle cell differentiation
GO:51932; synaptic transmission, GABAergic
GO:70301; cellular response to hydrogen peroxide
GO:70314; G1 to G0 transition
GO:70734; histone H3-K27 methylation
GO:71168; protein localization to chromatin
GO:97421; liver regeneration
GO:98532; histone H3-K27 trimethylation
GO:1900006; positive regulation of dendrite development
GO:1900016; negative regulation of cytokine production involved in inflammatory response
GO:1904772; response to tetrachloromethane
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:43547; positive regulation of GTPase activity
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:48387; negative regulation of retinoic acid receptor signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:6355; regulation of transcription, DNA-templated
GO:45814; negative regulation of gene expression, epigenetic
GO:43406; positive regulation of MAP kinase activity
GO:1902808; positive regulation of cell cycle G1/S phase transition
GO:31509; subtelomeric heterochromatin assembly
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:45202; synapse
GO:5677; chromatin silencing complex
GO:5721; pericentric heterochromatin
GO:5737; cytoplasm
GO:35098; ESC/E(Z) complex
GO:45120; pronucleus
GO:781; chromosome, telomeric region
Function: GO:18024; histone-lysine N-methyltransferase activity
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:3677; DNA binding
GO:3682; chromatin binding
GO:3714; transcription corepressor activity
GO:3723; RNA binding
GO:16279; protein-lysine N-methyltransferase activity
GO:42054; histone methyltransferase activity
GO:43021; ribonucleoprotein complex binding
GO:43565; sequence-specific DNA binding
GO:70878; primary miRNA binding
GO:1222; transcription corepressor binding
GO:1990841; promoter-specific chromatin binding
GO:46976; histone methyltransferase activity (H3-K27 specific)
Hide GO terms

Homologs of EZH2 in Model Organisms

Danio rerio
ezh2
Mus musculus
Ezh2
Rattus norvegicus
Ezh2

In other databases

CellAge gene expression
  • This gene is present as EZH2

External links

OMIM
601573
Ensembl
ENSG00000106462
Entrez Gene
2146
UniGene
732308
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EZH2
GeneCards
EZH2